5-乙基-2-降冰片烯的体外遗传毒理学研究

Toxic substance mechanisms Pub Date : 1998-04-01 DOI:10.1080/107691898229378

B. Ballantyne

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引用次数: 3

摘要

5-乙基-2-降冰片烯(ENB, CAS No. 16219-75-3)是一种工业化学品，通过一系列体外试验研究了其潜在的遗传毒性。在鼠伤寒沙门氏菌TA1535、TA1537和TA1538的代谢激活下，或在中国仓鼠卵巢(CHO)细胞正向基因突变试验(HGPRT位点)中，均未发生致突变活性。姐妹染色单体交换试验在有或没有代谢激活的CHO细胞中未见效果。同样对CHO细胞进行的细胞遗传学研究显示，在存在或不存在代谢激活的情况下，服用ENB后，异常细胞没有增加。研究结果表明，ENB不具有致突变或致裂潜能。TA98, TA100，

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IN VITRO GENETIC TOXICOLOGY INVESTIGATIONS WITH 5-ETHYLIDENE-2-NORBORNENE

5-Ethylidene-2-norbornene (ENB, CAS No. 16219-75-3), an industrial chemical, was investigated for genotoxic potential with a battery of in vitro tests. No mutagenic activity occurred in the presence or absence of m etabolic activation with a Salmonella typhimurium TA1535, TA1537, and TA1538, or in a Chinese hamster ovary (CHO) cell forward gene mutation assay (HGPRT locus). No effect was seen in a sister chromatid exchange test in CHO cells, with or without metabolic activation. A cytogenetic study, also conducted with CHO cells, did not show any increase in aberrant cells following dosing with ENB in the presence or absence of m etabolic activation. The findings suggest an absence of a m utagenic or clastogenic potential for ENB. reverse assay with strains TA98, TA100,

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Toxic substance mechanisms

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