{"title":"乙醇脂质体凝胶包裹氨苯砜和抗生素治疗麻风病的开发、表征和经皮给药","authors":"R. Tiwari, G. Tiwari, P. Wal, A. Wal, P. Maurya","doi":"10.2174/1875933501805010001","DOIUrl":null,"url":null,"abstract":"Received: November 30, 2017 Revised: April 5, 2018 Accepted: April 16, 2018 Abstract: Background and Objective: Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good watersolubility and biocompatibility. The aim of present study was to prepare and characterize ethosomes of antileprotic drug Dapsone (DAP) together with an antibiotic Cloxacillin Sodium (CLXS) which may deliver these drugs to targeted site more efficiently than marketed gel preparation of DAP and also overcome the problems related with oral administration of CLXS.","PeriodicalId":22993,"journal":{"name":"The Open Nanomedicine Journal","volume":"82 1","pages":"1-15"},"PeriodicalIF":0.0000,"publicationDate":"2018-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":"{\"title\":\"Development, Characterization and Transdermal Delivery of Dapsone and an Antibiotic Entrapped in Ethanolic Liposomal Gel for the Treatment of Lapromatous Leprosy\",\"authors\":\"R. Tiwari, G. Tiwari, P. Wal, A. Wal, P. Maurya\",\"doi\":\"10.2174/1875933501805010001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Received: November 30, 2017 Revised: April 5, 2018 Accepted: April 16, 2018 Abstract: Background and Objective: Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good watersolubility and biocompatibility. The aim of present study was to prepare and characterize ethosomes of antileprotic drug Dapsone (DAP) together with an antibiotic Cloxacillin Sodium (CLXS) which may deliver these drugs to targeted site more efficiently than marketed gel preparation of DAP and also overcome the problems related with oral administration of CLXS.\",\"PeriodicalId\":22993,\"journal\":{\"name\":\"The Open Nanomedicine Journal\",\"volume\":\"82 1\",\"pages\":\"1-15\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open Nanomedicine Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1875933501805010001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open Nanomedicine Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1875933501805010001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Development, Characterization and Transdermal Delivery of Dapsone and an Antibiotic Entrapped in Ethanolic Liposomal Gel for the Treatment of Lapromatous Leprosy
Received: November 30, 2017 Revised: April 5, 2018 Accepted: April 16, 2018 Abstract: Background and Objective: Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good watersolubility and biocompatibility. The aim of present study was to prepare and characterize ethosomes of antileprotic drug Dapsone (DAP) together with an antibiotic Cloxacillin Sodium (CLXS) which may deliver these drugs to targeted site more efficiently than marketed gel preparation of DAP and also overcome the problems related with oral administration of CLXS.
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