碳半胱氨酸对急性呼吸道病毒感染儿童咳嗽严重程度和局部黏膜免疫的影响

N. Geppe, M. Velikoretskaya, I. Ozerskaya, T. Kozhevnikova, R. M. Faizullina, S. Shatalina, N.K. Ziskina, E.A. Siderko
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引用次数: 0

摘要

目的:探讨糖半胱氨酸对急性呼吸道病毒感染(ARVI)患儿咳嗽及唾液分泌免疫球蛋白A (sIgA)水平的影响,以及唾液分泌免疫球蛋白A水平与咳嗽总指数的相关性。设计:多中心观察性研究。材料和方法。156名年龄大于2岁(4.4±1.2岁)的ARVI患儿纳入研究。所有患者均按年龄剂量给予糖半胱氨酸。分别于ARVI发病后第1 ~ 2天和第7 ~ 10天测定总咳嗽指数和唾液sIgA浓度。结果。发病第7 ~ 10天,98.7%的患者咳嗽总指数明显下降。唾液sIgA初始水平为26.49 (8.94;56.51) μg/ml,动力学- 30.07 (8.52;60.40) μg/ml(差异无统计学意义)。43.6%的患者动态sIgA水平升高,其中绝大多数患者显著升高——20%或更多。55.8%的患者动态sIgA浓度下降。第一次和第二次就诊时唾液中sIgA浓度存在显著相关性(p < 0.001)。咳嗽总指数与sIgA水平无显著相关性。结论。在用碳半胱氨酸治疗ARVI患者中,咳嗽有显著的积极动态。唾液中sIgA的浓度变化范围很广。在患有ARVI的儿童中,唾液中sIgA水平随时间的变化呈多向变化。进一步研究局部粘膜免疫机制有助于开发治疗和预防ARVI的新方法。关键词:糖半胱氨酸,唾液分泌性免疫球蛋白A,儿童急性呼吸道病毒感染,咳嗽,粘膜免疫
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Carbocysteine Influence on Cough Severity and Local Mucosal Immunity in Acute Respiratory Viral Infections in Children
Aim: To evaluate the effect of carbocysteine on cough and the level of secretory immunoglobulin A (sIgA) in saliva in children with acute respiratory viral infections (ARVI) and the presence of a correlation between the level of sIgA in saliva and the total cough index. Design: Multicentre observational study. Materials and methods. 156 children older than 2 years (4.4 ± 1.2 years) with ARVI were included in the study. All patients received carbocysteine at the age dosage. The total cough index and the concentration of sIgA in saliva were measured on days 1–2 and on days 7–10 from the onset of ARVI. Results. The total cough index significantly decreased in 98.7% of patients by the 7–10th day of illness. The level of sIgA in saliva was initially 26.49 (8.94; 56.51) μg/ml, in dynamics — 30.07 (8.52; 60.40) μg/ml (no significant differences were found). An increase in the level of sIgA in dynamics was noted in 43.6% of patients, and in the vast majority of them the increase was significant — 20% or more. A decrease in the concentration of sIgA in dynamics was noted in 55.8% of patients. A significant correlation was found between sIgA concentrations in saliva at the first and second visits (p < 0,001). There was no significant correlation between the total cough index and sIgA levels. Conclusion. A significant positive dynamic of cough was noted in patients with ARVI during treatment with carbocysteine. The concentration of sIgA in saliva varies within a wide range. A multidirectional change in the level of sIgA in saliva over time was noted in children with ARVI. Further study of the mechanisms of local mucosal immunity can help in the development of new approaches to the treatment and prevention of ARVI. Keywords: carbocysteine, secretory immunoglobulin A in saliva, acute respiratory viral infections in children, cough, mucosal immunity.
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