驱蚊剂避蚊胺(DEET)、啶虫脒(picaridin)、丙烯氰菊酯(prallethrin)和IR3535对冈比亚按蚊气味结合蛋白(OBP20)的分子对接研究

Entomon; internationale Zeitschrift fur die gesamte Insektenkunde Pub Date : 2023-06-30 DOI:10.33307/entomon.v48i2.888

Arunima Choudhury, Innifa Hasan, P. Gogoi, D. Haloi

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引用次数: 0

摘要

本研究采用AutoDock软件测定避蚊胺(DEET)、啶虫脒(picaridin)、丙烯氰菊酯(prallethrin)和IR3535组分与冈比亚按蚊(Anopheles gambiae say，双翅目，库蚊科)气味受体的结合亲和力或结合能。氯丙菊酯的结合能(ÄG)最高，为-10.55 kcal/mol，其次是picaridin (-7.1 kcal/mol)、DEET (-6.57 kcal/mol)和IR3535 (-5.6 kcal/mol)。通过比较自动对接后的结合能，确定哪种驱蚊剂最有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Efficacy of compounds used in mosquito repellents (DEET, picaridin, prallethrin and IR3535) against odorant binding protein (OBP20) of Anopheles gambiae: A molecular docking study

The study is to use AutoDock software to determine the binding affinity or binding energy of DEET, picaridin, prallethrin, and IR3535 components with the odorant receptor of the Anopheles gambiae say (Diptera, Culicidae) mosquito species. The binding energy (ÄG) of prallethrin was determined to be highest at -10.55 kcal/mol followed by picaridin at -7.1 kcal/mol, DEET at -6.57 kcal/mol and IR3535 at -5.6 kcal/mol being the lowest among all. By comparing their binding energy levels after AutoDocking, it is to decide which mosquito repellent is the most effective.

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Entomon; internationale Zeitschrift fur die gesamte Insektenkunde

CiteScore

0.40

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