乳腺癌中糖基因表达的计算机综合分析

IF 0.4 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
H. Kojo, Atsushi Doi, Y. Eguchi, T. Miyagishima, T. Taki, K. Makino, H. Terada
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引用次数: 0

摘要

为了阐明碳水化合物链改变在癌症中的作用,我们利用geo注册数据进行了计算机分析,研究了107种糖基因在乳腺癌发生和发展过程中的表达变化。比较43乳腺肿瘤和正常对照组配对(GSE15852)揭示了重要的24糖原,包括基因的表达变化5 N-acetylgalactosaminyltransferases, 3核苷酸糖转运蛋白,3 asparagine-linked glycosylation-involved酶2 N-acetylglucosaminyl转移酶,2 focusyltransferases 2 sulfotransferases 2硫酸酯酶,1粘多糖synthesis-involved酶,1糖基转移酶,1葡糖基转移酶,1 sialyltransferase,和1 n -乙酰氨基葡萄糖酶。此外,为了阐明特定糖基因的表达是否随癌症分期而改变,我们比较了浸润前和浸润性导管癌的基因表达(GDS2045)。6个糖基因的表达在GDS2045中发生了显著变化。值得注意的是,其中3个基因与碳水化合物链的磺化有关。糖基因的上调和下调与碳水化合物链的合成有关,并讨论了糖基因表达变化对肿瘤发生的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comprehensive In silico Analysis of the Expression of Glycogenes in Breast Cancer
To elucidate the role of alterations to carbohydrate chains in cancer, we investigated changes in the expression of 107 glycogenes with the onset and progression of breast cancer by conducting an in silico analysis using GEO-registered data. A comparison between 43 breast tumors and paired normal controls (GSE15852) revealed significant changes in the expression of 24 glycogenes including the genes for 5 N-acetylgalactosaminyltransferases, 3 nucleotide sugar transporters, 3 asparagine-linked glycosylation-involved enzymes, 2 N-acetylglucosaminyl transferases, 2 fucosyltransferases, 2 sulfotransferases, 2 sulfatases, 1 glycosaminoglycan synthesis-involved enzyme, 1 glycosyltransferase, 1 glucosyltransferase, 1 sialyltransferase, and 1 N-acetylglucosaminidase. Furthermore, to clarify whether the expression of particular glycogenes changed dependent on the stage of cancer, we compared gene expression between preinvasive and invasive ductal carcinomas (GDS2045). The expression of 6 glycogenes exhibited significant changes in GDS2045. Notably, 3 of these genes were related to the sulfonation of carbohydrate chains. The upand down-regulated glycogenes were related to the synthesis of carbohydrate chains and the effects of changes in the expression of glycogenes on oncogenesis were discussed.
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来源期刊
Chem-Bio Informatics Journal
Chem-Bio Informatics Journal BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
0.60
自引率
0.00%
发文量
8
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