卡泊泊与NVP功能化设计抗生素药物负载水凝胶敷料,以改善伤口管理

Baljit Singh, A. Dhiman
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引用次数: 11

摘要

在本工作中,为了更好的伤口护理,设计了一种抗生素药物负载碳水化合物聚(NVP)基水凝胶伤口敷料。通过SEM-EDX、AFM、FTIR、13CNMR、TGA/DTA/DTG、DSC和溶胀研究对聚合物薄膜进行了表征。除药物释放外,还研究了各种生物医学性能(即血液相容性、黏附性、氧渗透性、水蒸气透过率、微生物渗透、拉伸强度、破裂强度、回弹性、应力松弛和折叠耐力)。聚合物膜具有生物相容性、氧渗透性和水蒸气渗透性,可吸收模拟伤口液(11.37±0.31 g/g)。药物释放谱符合Case-II扩散机制,释放谱最符合Hixson-Crowell动力学模型。力学性能结果表明,聚合物薄膜的抗拉强度为0.65±0.12 nm -2,伸长率为119.38±14.26%,回弹性为25.49±0.72%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Functionalization of carbopol with NVP for designing antibiotic drug loaded hydrogel dressings for better wound management
In the present work an attempt has been made to design the antibiotic drug loaded carbopol-poly(NVP) based hydrogel wound dressings for better wound care. The polymer films were characterized by SEM-EDX, AFM, FTIR, 13CNMR, TGA/DTA/DTG, DSC, and swelling studies. Besides drug release, various biomedical properties (viz. blood compatibility, mucoadhesion, oxygen permeability, water vapour transmission rate, microbial penetration, tensile strength, bursting strength, resilience, stress relaxation, and folding endurance) have also been studied. The polymer films have been observed to be biocompatible, permeable to oxygen and water vapour and have absorbed simulated wound fluid 11.37±0.31 g/g of polymer film.The drug release profile followed the Case-II diffusion mechanism and release profile best fitted in Hixson-Crowell's kinetic models.Mechanical properties results showed that the polymer film had 0.65±0.12 Nmm-2 tensile strength, 119.38±14.26% elongationand 25.49±0.72% resilience.
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