锌转运蛋白ZIP7在肠道内稳态自我更新中的新作用

W. Ohashi, K. Hase, T. Fukada
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引用次数: 0

摘要

人们对锌的生物学意义及其在组织发育和维持组织稳态中的调节机制越来越感兴趣。肠上皮经历了一个持续的自我更新过程,以维持肠道内稳态。此外,这一过程的失调经常导致各种肠道疾病,包括炎症性肠病、溃疡和癌症。然而,锌依赖调节肠上皮细胞更新的分子基础尚不完全清楚。在本研究重点中,我们描述了锌转运蛋白ZIP7(在未分化上皮细胞中高度表达)在肠上皮自我更新过程中发挥关键作用,在剧烈增殖反应中减轻内质网应激。我们的研究结果也提供了证据,表明ZIP7对细胞内锌稳态的微调对于维持肠道上皮稳态至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emerging role of zinc homeostasis by zinc transporter ZIP7 in intestinal homeostatic self-renewal
There has been a growing interest in the biological significance of zinc and its regulatory mechanism in the development of tissue and in the maintenance of tissue homeostasis. The intestinal epithelium undergoes a continuous self-renewing process to maintain the intestinal homeostasis. Moreover, dysregulation of this process often causes various intestinal disorders including inflammatory bowel disease, ulcer, and cancer. However, the molecular basis of zinc-dependent regulation of intestinal epithelial cell turnover is not fully understood. In this research highlight, we describe that the zinc transporter ZIP7 (highly expressed in undifferentiated epithelial cells) plays a critical role in the intestinal epithelial self-renewal process by alleviating the ER stress during vigorous proliferative response. Our findings also provide evidence showing that the fine-tuning of intracellular zinc homeostasis by ZIP7 is essential to maintain epithelial homeostasis in the intestine.
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