利用多组学框架推进和完善考古牙石研究

Sterling L. Wright, K. Dobney, L. Weyrich
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引用次数: 8

摘要

牙结石(钙化牙菌斑)是一种跨文化的生物基质,它正在成为人类学家和口腔卫生专业人员的重要信息来源。它包含大量不同的生物分子,提供有关个人文化、饮食、祖先和健康的信息。大多数研究考古牙石的研究人员使用基因组或蛋白质组学方法,尽管现在有广泛的其他技术可用。然而,很少有研究利用高效的多组协议。缺乏整合是有问题的,因为这种方法在其他领域已被证明可以改善结果并加强解释。本文综述了三种多组学方法:(1)元蛋白质组与元基因组之间的相互作用;(2)宿主基因组与口腔宏基因组的关系;(3)表观基因组与宏基因组的关联。我们从土壤、植物、肠道和现代口腔微生物组的多组学研究中得出结论,以证明这种整合如何提供单组学方法无法实现的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advancing and refining archaeological dental calculus research using multiomic frameworks
ABSTRACT Dental calculus (calcified dental plaque) is a cross-cultural biological matrix that is emerging as a critical source of information for anthropologists and oral health professionals. It contains a multitude of diverse biomolecules, providing information about an individual’s culture, diet, ancestry, and health. Most researchers who study archaeological dental calculus use genomic or proteomic approaches, although a wide range of other techniques are now available. However, few studies have utilized efficient multiomic protocols. This lack of integration is problematic, as such approaches in other fields have proven to improve results and strengthen interpretations. Our review discusses three multiomic approaches: (1) interactions between the metaproteome and metagenome; (2) relationships between the host genome and oral metagenome; and, (3) associations between the epigenome and metagenome. We draw from multiomic studies on soil, plant, gut, and modern oral microbiomes to demonstrate how such integration can provide insights that are not attainable with single-omic approaches.
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