静脉激光血液照射对下肢血栓性静脉疾病患者淋巴静脉流出及体液和细胞免疫状态的影响

G. V. Yarovenko, S. Katorkin, A. Yashkov
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引用次数: 1

摘要

血栓后下肢静脉炎发生在14 - 29%的病例中,并在20 - 50%的患者下肢深静脉血栓形成后的头两年内发生。目的:应用静脉激光血液照射(ILBI)优化下肢血栓性静脉血栓病患者的预后。材料和方法。52例患者接受了ILBI治疗。根据临床标准将患者随机分为两组:闭塞期18例(组1)和再通期34例(组2)。ILBI疗程包括7次:照射功率3-15 mW,脉冲频率80-3000 Hz,照射时间5-15分钟。超声检查静脉流出量及腹股沟淋巴结参数。采用放射免疫扩散法检测血浆、血清中IgG、IgM、IgA水平;浊度法-测定免疫复合物;t淋巴细胞-由受体转化为红细胞。采用荧光-血清学和互补玫瑰结形成技术监测b淋巴细胞水平。结果和讨论。两组大血管线性血流量和容积血流量均无统计学意义的增加。1组大隐静脉线性血流增加5.2%;血流量升高至113.0±2.14 mL/min (p < 0.01)。第二组血流量下降4.1%。淋巴结收缩有统计学意义;髓质层变窄至0.32±0.05 cm (p < 0.05), IgG、IgM、CIC水平降低;t淋巴细胞增加60.2±1.7% (p < 0.05)。结论。静脉激光血液照射对下肢血栓性静脉疾病患者的静脉流出、淋巴结、体液和细胞免疫的影响为推荐将所讨论的技术应用于广泛的临床实践提供了理由。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of intravenous laser blood irradiation on lymphovenous outflow and the state of humoral and cellular immunity in patients with postthrombophlebitic disease of the lower extremities
Post-thrombophlebitis of lower extremities occurs in 14–29 % of cases and develops within the fi rst two years after the episode of deep vein thrombosis of lower extremities in 20–50 % of patients. Objective: to apply intravenous laser blood irradiation (ILBI) for optimizing outcomes in patients with post-thrombophlebitic disease of their lower extremities. Materials and methods. 52 patients were treated with ILBI. They were randomized into two groups by the following clinical criteria: stage of occlusion – 18 patients (Group 1) and stage of recanalization – 34 patients (Group 2). ILBI course included 7 sessions: irradiation power – 3–15 mW, pulse frequency – 80–3000 Hz, exposure time – 5–15 minutes. Parameters of venous outfl ow and inguinal lymph nodes were monitored by ultrasound examination. Radial immunodiffusion was used to determine levels of IgG, IgM and IgA in blood plasma and serum; turbidimetry – to determine immune complexes; T-lymphocytes – by the receptors to erythrocytes. B-lymphocyte level was monitored with luminescence-serological and complementary rosette formation techniques. Results and discussion. A statistically signifi cant increase in linear and volumetric blood fl ow in great vessels was revealed in both groups. In Group 1, linear blood fl ow in the great saphenous vein increased by 5.2 %; volumetric blood fl ow increased up to 113.0 ± 2.14 mL/min (p < 0.01). In Group 2, volumetric blood fl ow slowed down by 4.1 %. Lymph nodes contracted statistically signifi cantly; the medullary layer narrowed up to 0.32 ± 0.05 cm (p < 0.05), level of IgG, IgM and CIC decreased; number of T-lymphocytes increased up to 60.2 ± 1.7 % (p < 0.05). Conclusion. The revealed effects of intravenous laser blood irradiation at the venous outfl ow, lymph nodes and humoral and cellular immunity in patients with post-thrombophlebitic disease of lower extremities give a reason to recommend the implementation of the discussed technique into a wide clinical practice.
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期刊介绍: The main columns of "Chinese Journal of Laser Medicine & Surgery" include treatises, which report the latest research results in basic research and clinical trials in the field of laser medicine; comprehensive reviews of the latest research progress in laser medicine at home and abroad. In addition, there are short reports and excerpts from foreign journals, conference news and other columns. The journal has published a large number of papers on basic research on laser medicine and applied research in various clinical subjects, aiming to play a positive role in promoting the application of laser in medicine and improving the level of laser medicine research.
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