Serum Mannose Level and Its Association in Women with Polycystic Ovarian Syndrome: a Case Control Study of Al-Najaf City / 2020

Background: Polycystic ovarian syndrome is a common public health issue around the world. Insulin resistance and glucose intolerance play important role in the etiology of polycystic ovarian syndrome and the serum mannose is incorporated in metabolism of glucose. Aim of study: Determination of the association between serum mannose level and polycystic ovarian syndrome. Patients and Methods: A case control study enrolled eighty eight women were divided as forty four women with polycystic ovarian syndrome and forty four women without polycystic ovarian syndrome presented to outpatient clinic at Fertility Center/Al Sader Medical City and outpatient clinic of Al- Zahraa Teaching Hospital in Najaf city-Iraq during the period from 1st of February till 31st of December, 2020. Results: The mean Serum Mannose level of women with polycystic ovarian syndrome 7.37 was   significantly higher than mean serum mannose of controls 1.32 (p<0.001). Cutoff serum mannose level of 1.98 had acceptable validity results (90.9% sensitivity, 90.9% specificity, 94% PPV, 90.5% NPV and 90% accuracy). The means of serum level testosterone and luteinizing hormones were significantly higher among women with polycystic ovarian syndrome, while mean follicular stimulating hormone level was significantly lower among women with polycystic ovarian syndrome. Conclusions: The serum mannose level is significantly increased in women with polycystic ovarian syndrome which may indicate its possible role in the pathophysiology of polycystic ovarian syndrome.