{"title":"茴香水提物对四氧嘧啶致糖尿病小鼠肝脏保护作用的研究","authors":"Bhaskar Sharma , Md. Sufiyan Siddiqui , Shiv Shanker Kumar , Gurudyal Ram , Manisha Chaudhary","doi":"10.1016/j.jopr.2013.07.020","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Diabetes mellitus is one of the most common endocrine disorders accompanied with many metabolic syndromes. Use of herbal medicines has always been an option to treat a great number of diseases such as diabetes and its complications. The aim of the present study is to investigate the liver protective effects of <em>Syzygium cumini</em> seed extract in alloxan induced diabetic Swiss albino mice.</p></div><div><h3>Methods</h3><p>Eighteen Swiss albino mice (weighing 28–32 g) were randomly divided into control, alloxan treated and <em>S. cumini</em> treated mice group. Diabetes was induced in mice by injecting intraperitoneally alloxan monohydrate at dose of 150 mg/kg body weight. Aqueous extracts of <em>S. cumini</em> seed at dose of 250 mg/kg body weight were given orally in diabetic mice daily for three weeks after established LD<sub>50</sub> value.</p></div><div><h3>Results</h3><p>In diabetic mice, the SGOT, SGPT, Bilirubin and serum glucose levels were significantly increased in comparison with the control groups. Statistical analysis (<em>p</em> < 0.05) of the data indicated that aqueous extract of <em>S. cumini</em> were significantly decrease serum contents of liver enzymes (SGOT, SGPT and Bilirubin) as well as serum glucose in treated groups.</p></div><div><h3>Conclusion</h3><p>The results suggested that aqueous extracts of <em>S. cumini</em> seed possesses liver protective effect against alloxan induced diabetic mice.</p></div>","PeriodicalId":16787,"journal":{"name":"Journal of Pharmacy Research","volume":"6 8","pages":"Pages 853-858"},"PeriodicalIF":0.0000,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jopr.2013.07.020","citationCount":"20","resultStr":"{\"title\":\"Liver protective effects of aqueous extract of Syzygium cumini in Swiss albino mice on alloxan induced diabetes mellitus\",\"authors\":\"Bhaskar Sharma , Md. Sufiyan Siddiqui , Shiv Shanker Kumar , Gurudyal Ram , Manisha Chaudhary\",\"doi\":\"10.1016/j.jopr.2013.07.020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Diabetes mellitus is one of the most common endocrine disorders accompanied with many metabolic syndromes. Use of herbal medicines has always been an option to treat a great number of diseases such as diabetes and its complications. The aim of the present study is to investigate the liver protective effects of <em>Syzygium cumini</em> seed extract in alloxan induced diabetic Swiss albino mice.</p></div><div><h3>Methods</h3><p>Eighteen Swiss albino mice (weighing 28–32 g) were randomly divided into control, alloxan treated and <em>S. cumini</em> treated mice group. Diabetes was induced in mice by injecting intraperitoneally alloxan monohydrate at dose of 150 mg/kg body weight. Aqueous extracts of <em>S. cumini</em> seed at dose of 250 mg/kg body weight were given orally in diabetic mice daily for three weeks after established LD<sub>50</sub> value.</p></div><div><h3>Results</h3><p>In diabetic mice, the SGOT, SGPT, Bilirubin and serum glucose levels were significantly increased in comparison with the control groups. Statistical analysis (<em>p</em> < 0.05) of the data indicated that aqueous extract of <em>S. cumini</em> were significantly decrease serum contents of liver enzymes (SGOT, SGPT and Bilirubin) as well as serum glucose in treated groups.</p></div><div><h3>Conclusion</h3><p>The results suggested that aqueous extracts of <em>S. cumini</em> seed possesses liver protective effect against alloxan induced diabetic mice.</p></div>\",\"PeriodicalId\":16787,\"journal\":{\"name\":\"Journal of Pharmacy Research\",\"volume\":\"6 8\",\"pages\":\"Pages 853-858\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.jopr.2013.07.020\",\"citationCount\":\"20\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmacy Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0974694313003022\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmacy Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0974694313003022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Liver protective effects of aqueous extract of Syzygium cumini in Swiss albino mice on alloxan induced diabetes mellitus
Background
Diabetes mellitus is one of the most common endocrine disorders accompanied with many metabolic syndromes. Use of herbal medicines has always been an option to treat a great number of diseases such as diabetes and its complications. The aim of the present study is to investigate the liver protective effects of Syzygium cumini seed extract in alloxan induced diabetic Swiss albino mice.
Methods
Eighteen Swiss albino mice (weighing 28–32 g) were randomly divided into control, alloxan treated and S. cumini treated mice group. Diabetes was induced in mice by injecting intraperitoneally alloxan monohydrate at dose of 150 mg/kg body weight. Aqueous extracts of S. cumini seed at dose of 250 mg/kg body weight were given orally in diabetic mice daily for three weeks after established LD50 value.
Results
In diabetic mice, the SGOT, SGPT, Bilirubin and serum glucose levels were significantly increased in comparison with the control groups. Statistical analysis (p < 0.05) of the data indicated that aqueous extract of S. cumini were significantly decrease serum contents of liver enzymes (SGOT, SGPT and Bilirubin) as well as serum glucose in treated groups.
Conclusion
The results suggested that aqueous extracts of S. cumini seed possesses liver protective effect against alloxan induced diabetic mice.
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