代谢综合征患者脂联素水平的相关性研究

Apurv Singhal, Vedpal Singh Punia, Akash Bharti, Shaavi Mittal, Praveen Raman Mishra, Prem Kuma
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引用次数: 1

摘要

简介:代谢综合征(MetS),也称为胰岛素抵抗综合征,是一组心脏代谢症状,如高血压、空腹血糖升高或胰岛素抵抗。MetS是全球面临的最严重的公共卫生问题之一。当前研究的目的是确定其患病率,以及血液脂联素水平与MetS发展之间的关系。材料和方法:这项观察性横断面医院研究于2019年1月至2020年6月在印度北方邦大诺伊达Sharda医院医学科学与研究学院综合医学部进行。本研究招募了60名参加门诊或住院部的患者,他们确认同意并符合国际糖尿病联合会(IDF)的MetS纳入标准。本研究的最终样本量为60人,患病率为10%。这就是本研究的精度下降到±7.6%的原因,这意味着最终结果的精度可能会有±7.6%的变化。结果:根据研究结果,没有MetS的受试者平均更年轻,BMI更低,腰围也比那些有MetS的人更小。与MetS患者相比,他们的血压、脉搏率和空腹血糖水平都较低,而且在有MetS患者和没有MetS患者之间的脂质谱也有统计学上的显著差异。在没有MetS的人群中,平均血清脂联素浓度为15.79±2.90 mg/mL,而在有MetS的人群中,平均血清脂联素浓度为11.02±2.63 mg/mL (p<0.001)。将脂联素水平与由IDF定义的MetS的不同成分进行比较。表1显示了与MetS临床特征相关的平均脂联素浓度。作者发现,较低的脂联素水平与大多数特征有统计学上的显著联系。在一项多变量分析中,发现血清脂联素含量与收缩压呈显著负相关(r=-0.262;p<0.050), BMI (r=-0.288;P <0.050),总胆固醇(r=-0.515;P <0.001),低密度脂蛋白(r=-0.305;P <0.050)。结论:总而言之,目前的结果表明,在MetS的存在下,循环脂联素水平降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Study of Correlation of Adiponectin Levels in Metabolic Syndrome
Introduction: Metabolic syndrome (MetS), also known as insulin resistance syndrome, is described as a cluster of cardiometabolic symptoms such as high blood pressure, elevated fasting glucose, or insulin resistance. MetS is one of the most serious public health problems being faced globally. The purpose of the current investigation was to determine its prevalence, as well as the relationship between blood adiponectin levels and the development of MetS. Materials and Methods: This observational cross-sectional hospital-based study was performed in the Department of General Medicine, School of Medical Sciences and Research, Sharda Hospital, Greater Noida, Uttar Pradesh, India, from January 2019–June 2020. Sixty patients attending the medicine out- or inpatient department, who confirmed consent, and fit into the International Diabetes Federation (IDF) inclusion criteria for MetS, were recruited for this study. The final sample size for this study was found to be 60, with a prevalence of 10%. This is the reason the study’s precision decreased to ±7.6%, implying that the precision of the end result may vary by ±7.6%. Results: Subjects without MetS were on average younger, had a lower BMI, and had a smaller waist circumference than those who had MetS, according to the findings. They also had lower blood pressure, pulse rate, and fasting plasma glucose levels than the people with MetS, and there were statistically significant variations in lipid profiles between those with and without MetS. In people who did not have MetS, the mean serum adiponectin concentration was 15.79±2.90 mg/mL, whereas the mean serum adiponectin concentration in people who did have MetS was 11.02±2.63 mg/mL (p<0.001). The levels of adiponectin were compared with the different components of MetS as defined by the IDF. The mean adiponectin concentrations in connection to the clinical characteristics of MetS are shown in Table 1 . The authors discovered that lower adiponectin levels were statistically significantly linked with the majority of the characteristics. In a multivariate analysis, the serum adiponectin content was found to be significantly inversely associated to systolic blood pressure (r=-0.262; p<0.050), BMI (r=-0.288; p<0.050), total cholesterol (r=-0.515; p<0.001), and low-density lipoprotein (r=-0.305; p<0.050) in the study participants. Conclusion: In conclusion, the present results suggest that circulating levels of adiponectin are reduced in the presence of MetS.
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