Synergic antibacterial effect between Maillard reactive product (MRP) and hydrogen peroxide (H2O2) on Streptococcus mutans

Objectives: To evaluate the antibacterial activity of resin composite containing Maillard reactive product (MRP) and hydrogen peroxide (H2O2) on Streptococcus mutans (S. mutans), and to investigate the antibacterial mechanism involved. Methods: The growth of S. mutans was investigated after dental resin containing H2O2in the presence and absence of MRP, was immersed into bacterial solution. The effect of MRP on H2O2degradation was examined by the measurement of H2O2content. Results: The resin composite containing MRP and H2O2showed stable antibacterial activity compared with resin containing H2O2only, and the effect of MRP was speculated to be the suppression of H2O2degradation, and the presence of H2O2correlated with the antibacterial activity of resin composite. These results indicated that the antibacterial activity of resin composite containing MRP and H2O2on S. mutans was dependent on the presence of H2O2, and MRP suppressed the degradation of H2O2after combination with H2O2. EDTA also suppressed the degradation of H2O2. Conclusions: An antibacterial effect of resin composite containing MRP and H2O2on S. mutans was observed. The effect of MRP on H2O2might be a metal chelating action. Application of resin composite containing MRP and H2O2to a caries dentine could be an alternative therapy to or serve as an additional minimally invasive antibacterial treatment.