用冷冻干燥技术研制稳定注射制剂

Rajni K, Naresh Kalra, Hunny Dabas
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引用次数: 0

摘要

药物稳定性是影响药品质量的重要问题。冷冻干燥是一种可用于开发稳定药物的技术。本文介绍了一种利用冷冻干燥法制备常规药物的新技术,在医药工业中具有广泛的应用前景。本综述旨在通过冷冻干燥技术将现有的不稳定系统改善为稳定系统。系统是危险的,这会导致药物的降解。冷冻干燥工艺可用于音响系统。蛋白质和多肽的特性是制药工业最关心的问题。冷冻干燥提供了一种新的、安全的、有效的方法来保存这些物质,而不需要冷藏或冷冻。在制药行业,许多努力已经作出了改善目前的注射用蛋白质配方。一种被称为冷冻干燥的新技术正在成为一种潜在的解决方案。本文将更详细地探讨冷冻干燥的特点及其开发稳定药物的可能性。尤其是复杂的蛋白质类药物,它们的稳定性很低,而且通常需要在恶劣的条件下储存,比如一直冷冻或在冰上冷却,这给制造商带来了巨大的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of Stable Injectable Formulation by Freeze Drying Technique
Drug stability is a significant problem that affects drug quality. Freeze drying is one of the techniques that can be used to develop stable drugs. This paper presents a new technique for developing regular drugs by a freeze-drying process with the potential for various applications in and the pharmaceutical industry. This review aims to improve the current systems from unstable to stable by freeze drying technique. systems are dangerous, which leads to the degradation of the drug. The freeze-drying process can be used for sound systems. Characteristics of proteins and peptides are the primary concern of the pharmaceutical industry. Freeze drying provides a new, safe, and effective way to preserve these substances without refrigeration or freezing. In the pharmaceutical industry, many efforts have been made to improve current protein formulations for injection. A new technique called freeze drying is emerging as a potential solution. This paper will explore the characteristics of freeze-drying and its possibilities for developing stable drugs in more detail. Especially complex protein-based drugs present significant challenges to manufacturers because their stability is low, and they often have harsh conditions that need to be stored such as being kept frozen or cooled on ice at all times.
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