接受β受体阻滞剂或血管紧张素受体阻滞剂的高血压女性运动训练后心血管反应的不同:一项初步研究

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2022-04-23 DOI:10.1080/10641963.2022.2065290

Igor M Mariano, A. Amaral, Victor Hugo V Carrijo, J. G. Costa, M. D. L. Rodrigues, T. Cunha, G. Puga

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引用次数: 1

摘要

【摘要】目的探讨β受体阻滞剂或血管紧张素受体阻滞剂对绝经后高血压妇女运动训练后心血管反应的影响。方法将绝经后妇女分为健康对照组(CON;N = 9);血管紧张素受体阻滞剂使用者;N = 19);β-肾上腺素受体阻滞剂使用者(BB;N = 19)。在12周(有氧和阻力)联合运动训练前后，通过心率(HR)及其变异性(HRV)，应激下血压(BP)(冷压和Stroop颜色试验)和动态血压及其变异性来评估他们。结果在动态血压分析中，只有ARB组清醒时收缩压降低(p = 0.011;ARB: 122±11 ~ 117±9;BB:从118±7到114±5;CON:从121±7到127±11 mmHg)。血压对应激的反应性存在时间效应，实验组和冷压试验后血压反应性均下降。在血压变异性分析中，只有BB组的收缩期SD24值显著降低(p = 0.007;Δarb =−0.3±2.0;Δbb =−1.3±2.0;ΔCON = 0.8±1.7 mmHg)和SDdn (p = 0.006;Δarb =−0.2±1.6;Δbb =−1.3±2.0;ΔCON = 0.4±2.1 mmHg)。HRV分析显示，训练后，只有BB组LF/HF降低(p = .001;Δarb = 0.1±0.8;Δbb =−0.4±1.5;Δcon = 1.0±1.7)。结论ARB对清醒时动态收缩压有明显的反应，而β受体阻滞剂对血压变异性有更大的反应。除此之外，运动可以减轻血压对压力的反应，两组之间没有差异。最后，两组HRV无显著差异。临床试验注册网站:Clinicaltrials.gov, NCT03529838

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Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study

ABSTRACT Aim To verify the influence of β-blockers or angiotensin receptor blockers on cardiovascular responses to exercise training in hypertensive post-menopausal women. Methods Postmenopausal women were allocated into: healthy control group (CON; n = 9); angiotensin receptor blockers users (ARB; n = 19); and β-adrenergic blockers users (BB; n = 19). Before and after 12 weeks of combined (aerobic and resistance) exercise training they were evaluated by: heart rate (HR) and its variability (HRV), blood pressure (BP) under stress (Cold pressor and Stroop color tests), and ambulatorial BP and its variability. Results In ambulatorial BP analysis only in ARB group awake systolic BP decreased (p = .011; ARB: From 122 ± 11 to 117 ± 9; BB: From 118 ± 7 to 114 ± 5; CON: From 121 ± 7 to 127 ± 11 mmHg). There were time effects in BP reactivity to stress, where BP reactivity after Stroop color and Cold pressor test decreased in all groups. In BP variability analysis, only BB group has significative decreased values in systolic SD24 (p = .007; ΔARB = −0.3 ± 2.0; ΔBB = −1.3 ± 2.0; ΔCON = 0.8 ± 1.7 mmHg) and SDdn (p = .006; ΔARB = −0.2 ± 1.6; ΔBB = −1.3 ± 2.0; ΔCON = 0.4 ± 2.1 mmHg). HRV analysis demonstrated that post-training, only in BB group LF/HF decreased (p = .001; ΔARB = 0.1 ± 0.8; ΔBB = −0.4 ± 1.5; ΔCON = 1.0 ± 1.7). Conclusion ARB present pronounced responses in awake ambulatorial systolic BP, while β-blockers users present greater responses in BP variability. Besides that, exercise can mitigate BP reactivity to stress with no differences between groups. Lastly, there were no major differences in HRV. Trial registry at “Clinicaltrials.gov” NCT03529838

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.