雷瓦斯汀贴片引起的高血压是一种罕见的副作用

IF 0.3 4区医学 Q4 GERIATRICS & GERONTOLOGY

International Journal of Gerontology Pub Date : 2019-01-01 DOI:10.6890/IJGE.201912_13(4).0021

C. Huang, Chia Ming Chang, H. Tu

{"title":"雷瓦斯汀贴片引起的高血压是一种罕见的副作用","authors":"C. Huang, Chia Ming Chang, H. Tu","doi":"10.6890/IJGE.201912_13(4).0021","DOIUrl":null,"url":null,"abstract":"Among older adults, Alzheimer disease (AD) is a worldwide health problem that causes functional disorders in memory, cognition, learning, behavior, and attention. 3 Cholinergic neurons are deficient in patients with AD. Rivastigmine is a new-generation agent that compensates for the lack of acetylcholine secretion in AD. 5 The Food & Drug Administration approved the rivastigmine patch in July 2007. However, the adverse drug reactions that occur in less than 5% of cases clinically are less attractive. The changes in blood pressure and heart rate induced by cholinesterase inhibitor (ChEI) have rarely been described. We report a patient who exhibited cholinergic-associated symptoms of nausea, vomiting, and high blood pressure induced by the larger dose of rivastigmine patch.","PeriodicalId":50321,"journal":{"name":"International Journal of Gerontology","volume":"13 3 1","pages":"363-364"},"PeriodicalIF":0.3000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High blood pressure induced by the rivastigmine patch as an uncommon side effect\",\"authors\":\"C. Huang, Chia Ming Chang, H. Tu\",\"doi\":\"10.6890/IJGE.201912_13(4).0021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Among older adults, Alzheimer disease (AD) is a worldwide health problem that causes functional disorders in memory, cognition, learning, behavior, and attention. 3 Cholinergic neurons are deficient in patients with AD. Rivastigmine is a new-generation agent that compensates for the lack of acetylcholine secretion in AD. 5 The Food & Drug Administration approved the rivastigmine patch in July 2007. However, the adverse drug reactions that occur in less than 5% of cases clinically are less attractive. The changes in blood pressure and heart rate induced by cholinesterase inhibitor (ChEI) have rarely been described. We report a patient who exhibited cholinergic-associated symptoms of nausea, vomiting, and high blood pressure induced by the larger dose of rivastigmine patch.\",\"PeriodicalId\":50321,\"journal\":{\"name\":\"International Journal of Gerontology\",\"volume\":\"13 3 1\",\"pages\":\"363-364\"},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Gerontology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.6890/IJGE.201912_13(4).0021\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Gerontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.6890/IJGE.201912_13(4).0021","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

在老年人中，阿尔茨海默病(AD)是一种全球性的健康问题，它会导致记忆、认知、学习、行为和注意力方面的功能障碍。3 AD患者胆碱能神经元缺乏。利瓦斯汀是补偿阿尔茨海默病中乙酰胆碱分泌不足的新一代药物。2007年7月，美国食品和药物管理局批准了这种药贴。然而，临床上不到5%的病例发生的药物不良反应就不那么吸引人了。胆碱酯酶抑制剂(ChEI)引起的血压和心率变化很少被报道。我们报告了一位患者，他表现出胆碱能相关症状，包括恶心、呕吐和高血压，这些症状是由大剂量的利瓦斯汀贴片引起的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

High blood pressure induced by the rivastigmine patch as an uncommon side effect

Among older adults, Alzheimer disease (AD) is a worldwide health problem that causes functional disorders in memory, cognition, learning, behavior, and attention. 3 Cholinergic neurons are deficient in patients with AD. Rivastigmine is a new-generation agent that compensates for the lack of acetylcholine secretion in AD. 5 The Food & Drug Administration approved the rivastigmine patch in July 2007. However, the adverse drug reactions that occur in less than 5% of cases clinically are less attractive. The changes in blood pressure and heart rate induced by cholinesterase inhibitor (ChEI) have rarely been described. We report a patient who exhibited cholinergic-associated symptoms of nausea, vomiting, and high blood pressure induced by the larger dose of rivastigmine patch.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Gerontology 医学-老年医学

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal aims to publish original research and review papers on all fields of geriatrics and gerontology, including those dealing with critical care and emergency medicine. The IJGE aims to explore and clarify the medical science and philosophy in all fields of geriatrics and gerontology, including those in the emergency and critical care medicine. The IJGE is determined not only to be a professional journal in gerontology, but also a leading source of information for the developing field of geriatric emergency and critical care medicine. It is a pioneer in Asia. Topics in the IJGE cover the advancement of diagnosis and management in urgent, serious and chronic intractable diseases in later life, preventive medicine, long-term care of disability, ethical issues in the diseased elderly and biochemistry, cell biology, endocrinology, molecular biology, pharmacology, physiology and protein chemistry involving diseases associated with age. We did not limit the territory to only critical or emergency condition inasmuch as chronic diseases are frequently brought about by inappropriate management of acute problems.