Immediate responses of the autonomic nervous system to the balneofactors, their neuro-endocrine-immune accompaniments and predictors

Introduction. In previous studies of the Truskavets’ Scientific School of Balneology, it has been shown that in response to the use of Bioactive Water Naftussya (BAWN) the activity of the autonomic nervous system changes. However, the nature of the reaction is ambiguous and is conditioned by the constellation of the initial parameters of the body [15,16,24,28]. The immediate reactions of diuresis, gastric and pancreatic secretion, hemodynamics were also interspersed [2, 6, 9, 27, 28, 31]. In the context of the adaptogenic concept of the mechanism of action BAWN [22], it is also shown that the polyversive reactions of the autonomic nervous system are accompanied by changes in some parameters of the electroencephalogram, immunogram of blood and levels of adaptation hormones in it [14-16, 24, 28]. However, the issue of the specificity of immediate effects of BAWN on the nervous, endocrine and immune systems, that function interconnected as a triple complex [15, 21, 22, 28], is still relevant. The answer to this question can be obtained by comparing the reactions of the autonomic nervous system to BAWN with reactions to ordinary (daily) water on the one hand, and other natural adaptogens on the other hand. This is the objective of this study. Material and Methods. The objects of the observation were 15 volunteers-men (aged 26÷60 years, M±SD: 44±12 years) without any clinical diagnose but with a moderate dysfunction of neuroendocrine-immune complex (dysadaptation). At first volunteers filled in a questionnaire with the purpose of estimation of the level of the trait anxiety [29]. Then EEG was recorded for 25 sec by means of the hardware-software complex ‘NeuroCom Standard’ (producer KhAI Medica, Kharkiv, Ukraine) monopolar in 16 loci (Fp1, Fp2, F3, F4, F7, F8, C3, C4, T3, T4, P3, P4, T5, T6, O1, O2) by 10-20 international system, with the reference electrodes A and Ref on tassels of the ears. Among the options the average EEG amplitude (μV) was considered as well as the modal frequency (Hz), frequency deviation (Hz), index (%), coefficient of asymmetry (%), absolute (μV2/Hz) and relative (%) power spectrum density (SPD) of basic rhythms: β (35÷13 Hz), α (13÷8 Hz), θ (8÷4 Hz) and δ (4÷0,5 Hz) in all loci, according to the instructions of the device. In addition, the Laterality Index (LI) for SPD of each rhythm was calculated using the formula [18]: LI, % = Σ [200•(Right – Left)/(Right + Left)]/8. For each locus the Entropy (h) of normalized SPD was also calculated by using classical CE Shannon’s formula [30]: h= [SPDα•log2 SPDα + SPDβ•log2 SPDβ + SPDθ•log2 SPDθ + + SPDδ•log2 SPDδ]/log2 4