由编辑从本期杂志中选出的具有重要意义的文章

Eukaryotic Cell Pub Date : 2015-04-01 DOI:10.1128/ec.00034-15

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Article of Significant Interest Selected from This Issue by the Editors

Gjini et al. (p. 789 – 804) investigated how targeted disruption of the gene encoding Tet2, a DNA methylcytosine oxidase crucial for converting 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC), affects zebrafish hematopoiesis. Zebrafish homozygous for tet2 inactivation exhibited low levels of 5-hmC specifically in hematopoietic cells and developed myelodysplasia of the kidney marrow at 11 months of age. Over the next 10 months, this disorder evolved to anemia and myelodysplastic syndrome. The zebrafish model of tet2 loss described is ideal for small-molecule screens in embryos to identify compounds with specific activity against tet2 mutant hematopoietic stem cells.

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来源期刊

Eukaryotic Cell 生物-微生物学

自引率

0.00%

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审稿时长

1 months

期刊介绍： Eukaryotic Cell (EC) focuses on eukaryotic microbiology and presents reports of basic research on simple eukaryotic microorganisms, such as yeasts, fungi, algae, protozoa, and social amoebae. The journal also covers viruses of these organisms and their organelles and their interactions with other living systems, where the focus is on the eukaryotic cell. Topics include: - Basic biology - Molecular and cellular biology - Mechanisms, and control, of developmental pathways - Structure and form inherent in basic biological processes - Cellular architecture - Metabolic physiology - Comparative genomics, biochemistry, and evolution - Population dynamics - Ecology