全球生物数据联盟:迈向可持续的生物数据基础设施

Chuck Cook, Guy Cochrane
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引用次数: 0

摘要

生命和生物医学科学的进步完全依赖于生物数据资源——包括生物数据的数据库和围绕这些数据库的服务。这些生物数据资源支持科学家进行数据操作和跨管理、分析和发布新生成的数据,并访问已有的参考数据,共同构成了生命科学和生物医学研究的关键基础设施。我们熟悉的科学基础设施,例如欧洲核子研究中心(CERN)或平方公里阵列,都是独特的、建造的实体,由中央资助并在一个或多个可识别的地点管理。相比之下,生命科学的主要基础设施——由数据库和其他生物数据资源组成——是全球分布的,虚拟连接的,由多个来源资助的,并且不是作为一个协调的实体来管理的。虽然这种配置支持创新,但它不利于个体生物数据资源和整个基础设施的长期可持续性。全球生物数据联盟(GBC)将认识到这些挑战并承认缺乏可持续性所带来的威胁的生命科学研究资助组织聚集在一起。他们同意共同努力寻找提高可持续性的方法。在演讲中,我们将概述全球生物数据资源基础设施,特别关注为构成基础设施的资源提供持续长期资金的挑战。这将为会议上关注澳大利亚生物数据资源的其他演讲提供全球背景。我们将介绍GBC为理解和分类生物数据资源和整个生物数据资源基础设施所开展的一些工作,概述全球核心生物数据资源计划和清单项目,并介绍围绕可持续性和开放数据方法的利益相关者咨询过程。最后,我们将列出GBC正在采取的途径,让研究人员、信息学家、资助组织和其他利益相关者参与进来,以实现这些关键资源的更大可持续性
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Global Biodata Coalition: Towards a sustainable biodata infrastructure
Progress in life and biomedical sciences depends absolutely on biodata resources—databases comprising biological data and services around those databases. Supporting scientists in data operations and spanning management, analysis and publication of newly generated data and access to pre-existing reference data, these biodata resources together comprise a critical infrastructure for life science and biomedical research. Familiar scientific infrastructures—for example the Conseil Européen pour la Recherche Nucléaire (CERN) or the Square Kilometer Array, are distinct, constructed, physical entities that are centrally funded and managed at one or more identifiable locations. By contrast, the primary infrastructure of the life sciences—comprised of databases and other biological data resources—is globally distributed, virtually connected, funded from multiple sources, and is not managed as a coordinated entity. While this configuration supports innovation, it lends itself poorly to the long-term sustainability of individual biodata resources and of the infrastructure as a whole. The Global Biodata Coalition (GBC) brings together life science research funding organisations that recognise these challenges and acknowledge the threat that the lack of sustainability poses. They agree to work together to find ways to improve sustainability. In the presentation, we will provide an overview of the global biodata resource infrastructure, focusing in particular on challenges to providing sustained long-term funding to the resources that comprise the infrastructure. This will provide a global context to other presentations in the session, which focus on biodata resources in Australia. Covering some of the work that GBC has carried out to understand and classify biodata resources and the entire biodata resource infrastructure, we will outline the Global Core Biodata Resource programme and Inventory project and also introduce the stakeholder consultation processes around approaches to sustainability and open data. Finally, we will lay out the path GBC is taking to engage researchers, informaticians, funding organisations and other stakeholders in moving towards greater sustainability for these critical resources
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