A. Fatma, Ricco Christophe, E. Mehdi, S. Maité, Ben Ali Mamdouh, F.G.D.A. Clotilde
{"title":"bisacodyl及其去乙酰化代谢物DDPM的抗菌和抗癌活性","authors":"A. Fatma, Ricco Christophe, E. Mehdi, S. Maité, Ben Ali Mamdouh, F.G.D.A. Clotilde","doi":"10.3390/MOL2NET-04-06130","DOIUrl":null,"url":null,"abstract":"The antibacterial activity of bisacodyl and its deacetylated metabolite, DDPM was investigated against Gram-positive pathogens including Staphylococcus aureus (ATCC 9144), Micrococcus luteus (LB14110), Salmonella enterica (NCTC 6017) with minimal inhibitory concentration (MIC) ranging from 12.5 to 25 μg/mL, 6.25 to 12.5 μg/mL and 25 to 50 μg/mL respectively. The results of antibacterial activity against Gram-negative foodborne Pseudomonas aeruginosa (ATCC 9027), Escherichia coli (ATCC 8739), show MIC values between 12.5-25 μg/mL and 25-50 μg/mL. The antifungal activity was also evaluated against the opportunistic pathogenic yeast Candida albicans (ATCC 2091) with MIC ranging from 12.5 to 25 μg/mL. Furthermore, the anticancer activity was evaluated against epithelial cervical cancer cell line (ATCC, Manassas,VA, USA). The results obtained indicated that bisacodyl and its deacetylated metabolite, DDPM have a cytotoxic activity at 63.69 μg/mL and 16.7 μg/mL respectively.","PeriodicalId":20475,"journal":{"name":"Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial and anticancer activities of bisacodyl and it’s deacetylated metabolite DDPM\",\"authors\":\"A. Fatma, Ricco Christophe, E. Mehdi, S. Maité, Ben Ali Mamdouh, F.G.D.A. Clotilde\",\"doi\":\"10.3390/MOL2NET-04-06130\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The antibacterial activity of bisacodyl and its deacetylated metabolite, DDPM was investigated against Gram-positive pathogens including Staphylococcus aureus (ATCC 9144), Micrococcus luteus (LB14110), Salmonella enterica (NCTC 6017) with minimal inhibitory concentration (MIC) ranging from 12.5 to 25 μg/mL, 6.25 to 12.5 μg/mL and 25 to 50 μg/mL respectively. The results of antibacterial activity against Gram-negative foodborne Pseudomonas aeruginosa (ATCC 9027), Escherichia coli (ATCC 8739), show MIC values between 12.5-25 μg/mL and 25-50 μg/mL. The antifungal activity was also evaluated against the opportunistic pathogenic yeast Candida albicans (ATCC 2091) with MIC ranging from 12.5 to 25 μg/mL. Furthermore, the anticancer activity was evaluated against epithelial cervical cancer cell line (ATCC, Manassas,VA, USA). The results obtained indicated that bisacodyl and its deacetylated metabolite, DDPM have a cytotoxic activity at 63.69 μg/mL and 16.7 μg/mL respectively.\",\"PeriodicalId\":20475,\"journal\":{\"name\":\"Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/MOL2NET-04-06130\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/MOL2NET-04-06130","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Antimicrobial and anticancer activities of bisacodyl and it’s deacetylated metabolite DDPM
The antibacterial activity of bisacodyl and its deacetylated metabolite, DDPM was investigated against Gram-positive pathogens including Staphylococcus aureus (ATCC 9144), Micrococcus luteus (LB14110), Salmonella enterica (NCTC 6017) with minimal inhibitory concentration (MIC) ranging from 12.5 to 25 μg/mL, 6.25 to 12.5 μg/mL and 25 to 50 μg/mL respectively. The results of antibacterial activity against Gram-negative foodborne Pseudomonas aeruginosa (ATCC 9027), Escherichia coli (ATCC 8739), show MIC values between 12.5-25 μg/mL and 25-50 μg/mL. The antifungal activity was also evaluated against the opportunistic pathogenic yeast Candida albicans (ATCC 2091) with MIC ranging from 12.5 to 25 μg/mL. Furthermore, the anticancer activity was evaluated against epithelial cervical cancer cell line (ATCC, Manassas,VA, USA). The results obtained indicated that bisacodyl and its deacetylated metabolite, DDPM have a cytotoxic activity at 63.69 μg/mL and 16.7 μg/mL respectively.