4-乙酰基-2(3H)-苯并噻唑酮的合成:苯并恶唑酮化感物的硫生物异构体

Phosphorus Sulfur and Silicon and The Related Elements Pub Date : 2017-04-20 DOI:10.1080/10426507.2017.1321645

M. Gerova, Filip E. Svetoslavov, B. Shivachev, R. Nikolova, O. Petrov

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引用次数: 1

摘要

摘要为了制备一种新的苯并恶唑酮类化感物的仿生类似物，建立了4-乙酰基-2(3H)-苯并噻唑酮的多步合成方法。该化合物以市售邻甲苯胺为原料，总收率为23%。4-乙酰-2(3H)-苯并噻唑酮的结构经核磁共振波谱和x射线晶体学证实。

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Synthesis of 4-acetyl-2(3H)-benzothiazolone: Sulfur bioisostere of benzoxazolone allelochemicals

GRAPHICAL ABSTRACT ABSTRACT A multi-step methodology for the synthesis of 4-acetyl-2(3H)-benzothiazolone was developed in order to prepare a new biomimetic analogue of benzoxazolone allelochemicals. The compound was prepared from commercially available o-toluidine in 23% overall yield. The structure of 4-acethyl-2(3H)-benzothiazolone was confirmed by NMR spectroscopy and X-ray crystallography.

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Phosphorus Sulfur and Silicon and The Related Elements

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