阿特唑单抗在治疗三阴性乳腺癌中的作用

P. Luz, L. Bretes, A. Arede
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引用次数: 0

摘要

分别为36%和22%)。这些结果引起了广泛的争论,因为研究设计不允许在PDL1阳性患者中得出这些结论,并且只有在意图治疗人群的数据为阳性时才计划验证PDL-1阳性患者的OS。Impassion131试验也与IMpassion130试验的结果相矛盾,IMpassion130试验证实了在使用atezolizumab治疗TNBC方面需要进一步调查。该试验患者被分配到PFS, pd - l1阳性的Abstract三阴性乳腺癌(TNBC)通常用化疗治疗。然而,免疫疗法已被广泛建议作为TNBC患者的治疗选择,包括atezolizumab。本文旨在充分了解atezolizumab治疗TNBC的证据。需要更新和更好的生物标志物来选择更有可能从免疫治疗中获益的TNBC患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Atezolizumab in the Treatment of Triple- Negative Breast Cancer
versus placebo were 36% and 22%). These results have been widely debated since the study design did not allow drawing these conclusions in PDL1 positive patients and it was only planned to verify the OS in PDL-1 positive patients if the data were positive in the intention to treat population. The Impassion131 trial also contradicts the findings of the IMpassion130 trial which corroborates the need for further investigations in terms of the use of atezolizumab in the treatment of TNBC this trial patients were assigned to PFS the PD-L1-positive Abstract Triple-Negative Breast Cancer (TNBC) is commonly treated with chemotherapy. However, immunotherapy has been widely suggested as a treatment option for patients with TNBC, including atezolizumab. The present narrative article aims to fully understand the evidence of atezolizumab in the treatment of TNBC. Newer and better biomarkers are needed to select patients with TNBC that are more likely to benefit from immunotherapy.
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