铟介导硝基苯甲醛还原和烯丙基化的简易一锅操作及其应用

IF 2.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Bulletin of The Korean Chemical Society Pub Date : 2002-01-01 DOI:10.5012/BKCS.2002.23.9.1285

Y. Cho, K.‐H. Kang, J. Cha, K. Choi, A. Pae, H. Koh, M. Chang

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引用次数: 5

摘要

不同的硝基苯甲醛在水溶液中使用铟在盐酸的存在下同时烯丙化和还原，得到具有同丙烯醇和芳香胺功能的化合物。苯胺基同丙烯醇的连续保护和氧化为二氢吲哚酮和二氢喹诺酮类杂环化合物的合成提供了有益的前体物质，这些化合物可通过分子内环化反应高效合成。

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A Facile One-Pot Operations of Reduction and Allylation of Nitrobenzaldehydes Mediated by Indium and Their Applications

Various nitrobenzaldehydes were simultaneously allylated and reduced using indium in the presence of HCl in aqueous media to give compounds having both functionality of homoallylic alcohol and aromatic amine. Sequential protection of the amino gro up and oxidation of the anilinyl homoallylic alcohol provided useful precursors of heterocyclic compounds such as dihydroindolones and dihydroquinolones, which could be efficiently synthesized through intramolecular cyclization reaction.

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来源期刊

Bulletin of The Korean Chemical Society 化学-化学综合

CiteScore

3.40

自引率

23.50%

发文量

182

审稿时长

2.3 months

期刊介绍： The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.