紫薇叶、花和种子乙醇提取物的抗炎特性评价(1)白化大鼠角叉菜胶诱导急性炎症的研究

S. Pavithran, P. Sujatha
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引用次数: 0

摘要

紫薇的药性提示其对急性炎症有抗炎作用。本研究旨在探讨白藜芦醇叶、花、籽提取物(LELE、LEFE和LESE)对卡拉胶诱导大鼠急性炎症的抗炎作用。这种植物通常被称为印度的骄傲,指的是这种植物的各个部分,包括叶子、花和种子,它们被用作民间药物。在传统医学中,植物化学和抗炎活性已被证明在治疗炎症方面是有效的。定性植物化学研究表明,其含有甾体、萜类、苷类、多酚类化合物、氨基酸、皂苷、生物碱、黄酮类、还原糖、单宁等多种活性代谢产物。研究表明,白桦叶(LELE)、花(LEFE)和种子(LESE)的乙醇提取物具有抗炎活性。本文研究了白化大鼠角叉菜烯所致足跖水肿的抗炎作用,并与对照药和标准药双氯芬酸注射液进行了比较。实验植物提取物分别以250和500 mg/kg b.w.口服,然后注射角叉菜胶。在足部水肿评估中,在水肿形成的早期(0 min-3 h)和后期(4-6 h)测量足部体积。在急性炎症足跖模型中,乙醇提取物显著减轻足跖水肿。结果表明,高剂量500mg /kg b.w.时,叶和种子乙醇提取物的抑制率为42%,低于标准药物。低剂量的乙醇花提取物与低剂量的种子提取物相当;比标准低1%,比对照低2%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EVALUATION OF ANTI-INFLAMMATORY PROPERTIES OF ETHANOLIC LEAF, FLOWER AND SEED EXTRACTS OF LAGERSTROEMIA SPECIOSA (L.) PERS (LYTHRACEAE) AGAINST CARRAGEENAN-INDUCED ACUTE INFLAMMATION IN ALBINO RATS
Lagerstroemia speciosa medicinal properties suggest that it may have anti-inflammatory effects on acute inflammation. The present study was performed to investigate the anti-inflammatory effect of L. speciosa ethanolic leaf, flower, and seed extract (LELE, LEFE, and LESE) on carrageenan-induced acute inflammation in rats. This plant is commonly called Pride of India refers to the various parts of this plant, including the leaves, flowers, and seeds, which are used as folk medicine. It has been demonstrated that the phytochemical and anti-inflammatory activities are effective in the treatment of inflammatory conditions in traditional medicine. The qualitative phytochemical investigation of L. speciosa leaf, flower, and seed revealed that it contained steroids, terpenoids, glycosides, polyphenolic compounds, amino acids, saponins, alkaloids, flavonoids, reducing sugars, tannins, and many other active metabolites. Studies have shown active antiinflammatory ingredients in L. speciosa ethanolic extracts of leaf (LELE), flower (LEFE), and seed (LESE). The ethanolic extracts of L. speciosa (LELE, LEFE and LESE) were investigated for anti-inflammatory activity in carrageenan-induced paw edema in albino rats and compared to control and standard drug, Diclofenac injection. The experimental plant extracts were given orally at a concentration of 250 and 500 mg/kg b.w. before carrageenan injection. In the paw edema evaluation, the paw volume was measured in the early (from 0 min-3 h) and late (4-6 h) phases of edema formation. In acute inflammation paw models, the ethanol extracts significantly reduced paw edema. The result obtained is indicative that the ethanolic extract of leaf and seed with high dose of 500 mg/kg b.w. produced 42% of inhibition and is low as compared to the standard drug. Low dose of ethanolic flower extract of L. speciosa inhibitory is equal to the low dose of seed extract; it is 1% lower than the standard and 2% lower than the control.
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