{"title":"反复亚麻醉暴露后大鼠组织中的氟烷。","authors":"M. Wolff","doi":"10.1097/00132586-197806000-00016","DOIUrl":null,"url":null,"abstract":"Halothane in tissues of the rat has been measured as a function of time after five successive 3 hr exposures to 670 ppm halothane. In epididymal and perirenal fat, halothane concentrations diminished rapidly from 310 ppm to 1-2 ppm in 24 hr, with trace amounts detectable 5 days later. Brain and liver levels were reduced from 16 and 9 ppm to less than 1 ppm within 3 hr. Blood halothane was reduced from 3 ppm to less than 0.5 ppm in the same time.","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":"71 1","pages":"1079-83"},"PeriodicalIF":0.0000,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Halothane in tissue of rats following repeated subanesthetic exposures.\",\"authors\":\"M. Wolff\",\"doi\":\"10.1097/00132586-197806000-00016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Halothane in tissues of the rat has been measured as a function of time after five successive 3 hr exposures to 670 ppm halothane. In epididymal and perirenal fat, halothane concentrations diminished rapidly from 310 ppm to 1-2 ppm in 24 hr, with trace amounts detectable 5 days later. Brain and liver levels were reduced from 16 and 9 ppm to less than 1 ppm within 3 hr. Blood halothane was reduced from 3 ppm to less than 0.5 ppm in the same time.\",\"PeriodicalId\":17418,\"journal\":{\"name\":\"Journal of Toxicology and Environmental Health, Part A\",\"volume\":\"71 1\",\"pages\":\"1079-83\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Toxicology and Environmental Health, Part A\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/00132586-197806000-00016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Toxicology and Environmental Health, Part A","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/00132586-197806000-00016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Halothane in tissue of rats following repeated subanesthetic exposures.
Halothane in tissues of the rat has been measured as a function of time after five successive 3 hr exposures to 670 ppm halothane. In epididymal and perirenal fat, halothane concentrations diminished rapidly from 310 ppm to 1-2 ppm in 24 hr, with trace amounts detectable 5 days later. Brain and liver levels were reduced from 16 and 9 ppm to less than 1 ppm within 3 hr. Blood halothane was reduced from 3 ppm to less than 0.5 ppm in the same time.
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