异基因干细胞移植后由三磷酸体墨染引起的致死性侵袭性三磷酸体病治疗特发性再生障碍性贫血

Daphné Krzisch, V. Camus, Marion David, G. Gargala, S. Lepretre
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引用次数: 2

摘要

侵袭性三磷丝素真菌感染是罕见和不寻常的,几乎只发生在恶性血液病或其他免疫缺陷疾病治疗期间经历长期中性粒细胞减少的免疫功能低下患者中。我们报告一例27岁的严重再生障碍性贫血患者,在骨髓同种异体干细胞移植后,在发育不全期间发生了三磷酸丝氨酸蛋白脓毒症和皮肤病变。他接受两性霉素B脂质体治疗,但死于多器官衰竭。然后,我们讨论流行病学,临床和治疗的特点,这些严重的真菌感染与已发表的数据进行比较。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fatal Invasive Trichosporonosis Caused by Trichosporon inkin after Allogeneic Stem Cell Transplant for very Severe Idiopathic Aplastic Anemia
Invasive Trichosporon inkin fungal infections are rare and unusual, occurring nearly exclusively in immunocompromised patients experiencing prolonged neutropenia during treatment of malignant hemopathies or other immunodeficiency conditions. We report a case of a 27-year-old patient with severe aplastic anemia who developed Trichosporon inkin sepsis with skin lesions during aplasia after myeloablative allogeneic stem cell transplant. He was treated with liposomal amphotericin B but died from multiple organ failure. We then discuss the epidemiological, clinical and therapeutic features of these serious fungal infections compared to the published data.
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