同型半胱氨酸、酒精中毒及其潜在的表观遗传机制。

IF 3.2 3区医学 Q1 Medicine

Alcoholism, clinical and experimental research Pub Date : 2016-11-02 DOI:10.1111/acer.13234

P. Kamat, C. J. Mallonee, Akash K. George, S. Tyagi, N. Tyagi

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引用次数: 49

摘要

酒精是社会上最容易让人上瘾的药物。饮酒与一些健康问题有关，如神经、认知、行为缺陷、癌症、心脏和肝脏疾病。酒精引起的毒性机制目前尚不清楚。酒精毒性的一个潜在机制与它与氨基酸同型半胱氨酸(Hcy)的相互作用有关，而Hcy与脑神经毒性有关。Hcy升高会损害机体的多种生理机制，尤其是代谢途径。Hcy代谢主要受表观遗传调控控制，如DNA甲基化、组蛋白修饰和乙酰化。这些过程的改变导致表观遗传修饰。因此，本文就Hcy代谢异常在酒精毒性中表观遗传适应的作用及其对脑血管病理的影响进行综述。

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Homocysteine, Alcoholism, and Its Potential Epigenetic Mechanism.

Alcohol is the most socially accepted addictive drug. Alcohol consumption is associated with some health problems such as neurological, cognitive, behavioral deficits, cancer, heart, and liver disease. Mechanisms of alcohol-induced toxicity are presently not yet clear. One of the mechanisms underlying alcohol toxicity has to do with its interaction with amino acid homocysteine (Hcy), which has been linked with brain neurotoxicity. Elevated Hcy impairs with various physiological mechanisms in the body, especially metabolic pathways. Hcy metabolism is predominantly controlled by epigenetic regulation such as DNA methylation, histone modifications, and acetylation. An alteration in these processes leads to epigenetic modification. Therefore, in this review, we summarize the role of Hcy metabolism abnormalities in alcohol-induced toxicity with epigenetic adaptation and their influences on cerebrovascular pathology.

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来源期刊

Alcoholism, clinical and experimental research 医学-药物滥用

CiteScore

5.90

自引率

9.40%

发文量

219

审稿时长

1 months

期刊介绍： Alcoholism: Clinical and Experimental Research''s scope spans animal and human clinical research, epidemiological, experimental, policy, and historical research relating to any aspect of alcohol abuse, dependence, or alcoholism. This journal uses a multi-disciplinary approach in its scope of alcoholism, its causes, clinical and animal effect, consequences, patterns, treatments and recovery, predictors and prevention.