以烟酸及其异构体、3-羟基吡啶和3-吡啶乙醇为基础的二硫代磷酸吡啶盐

Phosphorus Sulfur and Silicon and The Related Elements Pub Date : 2020-03-03 DOI:10.1080/10426507.2019.1673749

I. Nizamov, R. Salikhov, I. D. Timushev, Yevgeniy N. Nikitin, I. Nizamov, V. Y. Yakimov, M. Shulaeva, O. K. Pozdeev, E. S. Batyeva, R. Cherkasov, A. S. Ponomareva

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引用次数: 4

摘要

摘要以(1S)-内切-(-)-冰片为基础，以烟酸、异烟酸、吡啶酸和二硫代磷酸为原料，在苯或乙醇中合成了一系列新的手性二硫代磷酸羧基吡啶。5,5-二甲基-2-巯基-2-硫离子-1,3,2-二磷磷烷与3-羟吡啶或3-吡啶乙醇在乙氢氧合中反应得到具有抗白色念珠菌活性的3-羟吡啶和3-羟甲基吡啶5,5-二甲基-2-巯基-1,3,2-二磷磷烷。图形抽象

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Pyridinium salts of dithiophosphoric acids on the basis of nicotinic acids and their isomers, 3-hydroxypyridine, and 3-pyridinemethanol

Abstract A new series of chiral carboxypyridinium dithiophosphates were synthesized by the reactions of nicotinic, isonicotinic, and picolinic acids with dithiophosphoric acid on the basis (1S)-endo-(–)-borneol in benzene or ethanol. 5,5-Dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinane reacted with 3-hydroxypyridine or 3-pyridinemethanol in EtOH to afford the 3-hydroxypyridinium and 3-hydroxymethylpyridinium 5,5-dimethyl-2-mercapto-2-thiono-1,3,2-dioxaphosphorinanes which possessed antifungal activity against Candida albicans. Graphical Abstract

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Phosphorus Sulfur and Silicon and The Related Elements

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