类风湿关节炎患者血清补体成分1q肿瘤坏死因子相关蛋白3及补体成分1q肿瘤坏死因子相关蛋白9水平的临床意义

Xin Li, Yuan Wang, Xiaoxia Jia, Jing Ke, Baoyu Zhang, Yan Wang
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摘要

目的:评价血清补体成分1q肿瘤坏死因子相关蛋白3 (CTRP3)和CTRP9在类风湿关节炎(RA)患者中的表达,进一步探讨其与疾病活动度的相关性及对RA的预测价值。方法:选取首都医科大学附属北京潞河医院RA组(n = 60)和健康组(n = 60)。我们收集临床资料,包括基本信息、实验室参数和疾病活动度评分(DAS28)评分,并采用酶联免疫吸附法测定两组患者血清CTRP3和CTRP9的表达。分析血清CTRP3、CTRP9与RA的相关性。探讨血清CTRP3和CTRP9对RA的预测价值。结果:与健康组比较,RA组血清CTRP3、CTRP9表达明显升高(P < 0.05)。RA患者除类风湿因子(血清CTRP9: r = - 0.310, P = 0.018)、免疫球蛋白(血清CTRP9: r = 0.338, P = 0.010)外,血小板、红细胞沉降率、c反应蛋白、DAS28、抗环氨酸肽抗体、甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白等与血清CTRP3、CTRP9水平无关。血清CTRP3和CTRP9的最佳临界值分别为31.66和34.39 ng/ml。在敏感性、阴性预测值和准确性方面,与单独检测血清CTRP3或CTRP9相比,联合检测对RA的预测价值更高。结论:CTRP3和CTRP9可能成为RA的两种候选生物标志物。血清CTRP3和CTRP9可能对RA有一定的预测价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The clinical significance of serum complement component 1q tumor necrosis factor-related protein 3 and complement component 1q tumor necrosis factor-related protein 9 levels in patients with rheumatoid arthritis
Objective: The objective of this study was to assess the expression of serum complement component 1q tumor necrosis factor-related protein 3 (CTRP3) and CTRP9 in rheumatoid arthritis (RA) patients, and further explore their correlation with disease activity and the predictive value of RA. Methods: RA group (n = 60) and healthy group (n = 60) were enrolled in Beijing Luhe Hospital, Capital Medical University. We collected the clinical data, including the basic information, laboratory parameters as well as the Disease Activity Score using 28 joint counts (DAS28) scores, and measured the expression of serum CTRP3 and CTRP9 in two groups by enzyme-linked immunosorbent assay. To analyze the correlation between serum CTRP3 and CTRP9 and RA. We explored the predictive value of the serum CTRP3 and CTRP9 for RA. Results: Compared to the healthy group, the expression of serum CTRP3 and CTRP9 was higher in the RA group (P < 0.05). Except rheumatoid factor (serum CTRP9: r = −0.310, P = 0.018), and immunoglobulin (serum CTRP9: r = 0.338, P = 0.010), platelet, erythrocyte sedimentation rate, C-reactive protein, DAS28, anti-cyclic citrullinated peptide antibody, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, etc., of RA patients were not related to the levels of serum CTRP3 and CTRP9. The best cutoff value of serum CTRP3 and CTRP9 was 31.66 and 34.39 ng/ml, respectively. In terms of sensitivity, negative predictive value, and accuracy, compared with single detection of serum CTRP3 or CTRP9, combined detection has more predictive value for RA. Conclusion: CTRP3 and CTRP9 may become two candidate biomarkers for RA. The serum CTRP3 and CTRP9 may have certain predictive values for RA.
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