B. Baragatti, V. Calderone, M. Breschi, E. Martinotti
{"title":"钾通道在GABA抑制豚鼠回肠电场刺激胆碱能反应中的作用","authors":"B. Baragatti, V. Calderone, M. Breschi, E. Martinotti","doi":"10.1211/146080899128734389","DOIUrl":null,"url":null,"abstract":"γ-Aminobutyric acid B (GABAB) receptor activation inhibits the cholinergic response to electrical field stimulation (EFS) in guinea-pig ileum. The involvement of potassium channels in this GABA inhibitory action was investigated. \n \n \n \nThe modulatory effect of GABA was not modified after pre-incubation of the organ with 1 mM tetraethylammonium chloride, a non-selective potassium channel antagonist. Nevertheless, the non-selective K+ channels antagonists, 4-aminopyridine (3 mM) and quinine (200 μM), and the selective KATP channel antagonist glibenclamide (1 μM), significantly reduced the inhibitory effects of GABA. \n \n \n \nThe results suggest a coupling between GABAB receptors and KATP channels in the guinea-pig ileum.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Role of Potassium Channels in the GABA Inhibitory Action on the Cholinergic Response to Electrical Field Stimulation in Guinea-pig Ileum\",\"authors\":\"B. Baragatti, V. Calderone, M. Breschi, E. Martinotti\",\"doi\":\"10.1211/146080899128734389\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"γ-Aminobutyric acid B (GABAB) receptor activation inhibits the cholinergic response to electrical field stimulation (EFS) in guinea-pig ileum. The involvement of potassium channels in this GABA inhibitory action was investigated. \\n \\n \\n \\nThe modulatory effect of GABA was not modified after pre-incubation of the organ with 1 mM tetraethylammonium chloride, a non-selective potassium channel antagonist. Nevertheless, the non-selective K+ channels antagonists, 4-aminopyridine (3 mM) and quinine (200 μM), and the selective KATP channel antagonist glibenclamide (1 μM), significantly reduced the inhibitory effects of GABA. \\n \\n \\n \\nThe results suggest a coupling between GABAB receptors and KATP channels in the guinea-pig ileum.\",\"PeriodicalId\":19946,\"journal\":{\"name\":\"Pharmacy and Pharmacology Communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacy and Pharmacology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1211/146080899128734389\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacy and Pharmacology Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1211/146080899128734389","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Role of Potassium Channels in the GABA Inhibitory Action on the Cholinergic Response to Electrical Field Stimulation in Guinea-pig Ileum
γ-Aminobutyric acid B (GABAB) receptor activation inhibits the cholinergic response to electrical field stimulation (EFS) in guinea-pig ileum. The involvement of potassium channels in this GABA inhibitory action was investigated.
The modulatory effect of GABA was not modified after pre-incubation of the organ with 1 mM tetraethylammonium chloride, a non-selective potassium channel antagonist. Nevertheless, the non-selective K+ channels antagonists, 4-aminopyridine (3 mM) and quinine (200 μM), and the selective KATP channel antagonist glibenclamide (1 μM), significantly reduced the inhibitory effects of GABA.
The results suggest a coupling between GABAB receptors and KATP channels in the guinea-pig ileum.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
