T. Porter, N. Murthy, P. Mourad, P. Stayton, A. Hoffman, L. Crum
{"title":"用表面活性聚合物控制空化引起的溶血","authors":"T. Porter, N. Murthy, P. Mourad, P. Stayton, A. Hoffman, L. Crum","doi":"10.1121/1.1909263","DOIUrl":null,"url":null,"abstract":"This study was performed to identify the affect of variations in the surface activity of the polymer poly(propylacrylic acid) (PPAA) on cavitation-induced hemolysis. The surface activity of PPAA was varied by changing the molecular weight (MW1=43 kDa and MW2=60 kDa) and the solution pH (pH=5.0, 6.1, and 7.4). Acoustic energy was delivered with a 1.1-MHz high-intensity focused ultrasound transducer. Comparing the two molecular weights, the 60-kDa polymer was a better agent for nucleating cavitation independent of the solution pH, and was a better agent for enhancing cavitation-induced hemolysis.","PeriodicalId":87384,"journal":{"name":"Acoustics research letters online : ARLO","volume":"12 1","pages":"201-206"},"PeriodicalIF":0.0000,"publicationDate":"2005-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Control of cavitation-induced hemolysis with a surface-active polymer\",\"authors\":\"T. Porter, N. Murthy, P. Mourad, P. Stayton, A. Hoffman, L. Crum\",\"doi\":\"10.1121/1.1909263\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study was performed to identify the affect of variations in the surface activity of the polymer poly(propylacrylic acid) (PPAA) on cavitation-induced hemolysis. The surface activity of PPAA was varied by changing the molecular weight (MW1=43 kDa and MW2=60 kDa) and the solution pH (pH=5.0, 6.1, and 7.4). Acoustic energy was delivered with a 1.1-MHz high-intensity focused ultrasound transducer. Comparing the two molecular weights, the 60-kDa polymer was a better agent for nucleating cavitation independent of the solution pH, and was a better agent for enhancing cavitation-induced hemolysis.\",\"PeriodicalId\":87384,\"journal\":{\"name\":\"Acoustics research letters online : ARLO\",\"volume\":\"12 1\",\"pages\":\"201-206\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acoustics research letters online : ARLO\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1121/1.1909263\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acoustics research letters online : ARLO","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1121/1.1909263","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Control of cavitation-induced hemolysis with a surface-active polymer
This study was performed to identify the affect of variations in the surface activity of the polymer poly(propylacrylic acid) (PPAA) on cavitation-induced hemolysis. The surface activity of PPAA was varied by changing the molecular weight (MW1=43 kDa and MW2=60 kDa) and the solution pH (pH=5.0, 6.1, and 7.4). Acoustic energy was delivered with a 1.1-MHz high-intensity focused ultrasound transducer. Comparing the two molecular weights, the 60-kDa polymer was a better agent for nucleating cavitation independent of the solution pH, and was a better agent for enhancing cavitation-induced hemolysis.