预防脾功能不全和脾功能不全患者的严重感染:文献综述

Q4 Medicine

Pediatriya - Zhurnal im G.N. Speranskogo Pub Date : 2023-04-21 DOI:10.24110/0031-403x-2023-102-2-89-99

М. Leonteva, E. Deordieva, G. Solopova, E. S. Nikonova, A. Shcherbina

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引用次数: 0

摘要

脾是免疫系统最重要的外周器官之一，由于其结合先天免疫和适应性免疫的能力，在调节免疫稳态中起着决定性的作用。脾功能减退(脾功能减退)和脾功能不全是肺炎链球菌、脑膜炎奈瑟菌和b型流感嗜血杆菌等包膜菌引起暴发性败血症的危险因素。脾切除术后系统和长期的治疗方法可显著降低脾功能减退和脾功能减退患者被包膜菌感染的风险。这篇文献综述代表了免疫学家和血液学家实践中最常见的脾功能不全和脾功能不足的几种形式，并强调了在这组患者中接种疫苗和预防性抗生素治疗的问题，因为这方面是预防致命并发症的长期观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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SEVERE INFECTIONS PREVENTION IN PATIENTS WITH ASPLENIA AND HYPOSPLENIA: A BIBLIOGRAPHICAL REVIEW

Spleen is one of the most important peripheral organs of the immune system because it plays a decisive role in the regulation of immune homeostasis due to its ability to bind innate and adaptive immunity. Reduced spleen function (hyposplenia) and asplenia are risk factors for the development of fulminant sepsis caused by encapsulated bacteria such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type b. Systematic and long-term treatment approaches after splenectomy can significantly reduce the risk of infection with encapsulated organisms among patients with asplenia and hyposplenism. This bibliographical review represents a few out of the most common forms of asplenia and hyposplenia in the immunologists’, hematologists’ practice and highlights the issue of vaccination and prophylactic antibiotic therapy in this group of patients as well since this aspect is a long-term perspective for preventing of fatal complications.

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来源期刊

Pediatriya - Zhurnal im G.N. Speranskogo Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.60

自引率

0.00%

发文量

150

期刊介绍： Journal “Pediatria” named after G.N. Speransky (the official short names of the Journal are “Journal «Pediatria»,” “Pediatria,” and “«Pediatria,» the Journal”) is the oldest Soviet-and-Russian (in the Russian Federation, the CIS and former Soviet Union) scientific and practical medical periodical assigned for pediatricians that is published continuously since May, 1922, and distributed worldwide. Our mission statement specifies that we aim to the ‘raising the level of skills and education of pediatricians, organizers of children’s health protection services, medicine scientists, lecturers and students of medical institutes for higher education, universities and colleges worldwide with an emphasis on Russian-speaking audience and specific, topical problems of children’s healthcare in Russia, the CIS, Baltic States and former Soviet Union Countries and their determination with the use of the World’s best practices in pediatrics.’ As part of this objective, the Editorial of the Journal «Pediatria» named after G.N. Speransky itself adopts a neutral position on issues treated within the Journal. The Journal serves to further academic discussions of topics, irrespective of their nature - whether religious, racial-, gender-based, environmental, ethical, political or other potentially or topically contentious subjects. The Journal is registered with the ISSN, - the international identifier for serials and other continuing resources, in the electronic and print world: ISSN 0031-403X (Print), and ISSN 1990-2182 (Online). The Journal was founded by the Academician, Dr. Georgiy Nestorovich SPERANSKY, in May, 1922. Now (since 1973) the Journal bears his honorary name.