ORAL MANIFESTATION ON SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS

Background: Periodontitis worldwide reported increasing 57.3% between 20 years also reported 6 th most prevalence disease around the world. Imune response abnormalities, hyperactivity of production of autoantibodies deposited in human tissue and organ could affect oral cavity condition. Objectives: To find oral manifestation on SLE patients and correlate with SLE severity. Methods: Subjects were 61 patients with SLE (age 17-51 years; diagnosed using SLICC) collected from Dr. Saiful Anwar General Hospital, Malang Indonesia. Oral Manidestation is measured by clinical examination and SLE severity measured using SLEDAI. Result: A total 61 SLE subjects  were included in this study. We found that 54 patients (88,53%) subjects with SLE had periodontitis. 7 subject had no periodontitis, 11 mild periodontitis, 43 severe periodontitis. There is correlation between oral condition and SLE severity.  Periodontitis and SLEDAI score showed significant (p<0.0001) and strong positive correlation (r=0.948) Discussion : Our study found high rates of gingivitis, periodontitis, bop, low plaque index, and low calculus index. SLE is chronic autoimmune disease develop autoantibodies and immune complexes, because of immune respon abnormalities.It could be forming autoantibodies cause DNA damage, lipid peroxidation, protein. This condition induce collagen breakdown, RANKL, osteoclast stimulation until alveolar bone resorption resulting poor oral condition and periodontitis. Conclusion: Our study showed that oral condition were associated with SLE disease activity Keywords: Oral Manifestation , Periodontitis; SLEDAI; SLE