Hideko Maeda, Kaori Morita, Ayaka Murokawa, Rika Matsuo, H. Nariai, H. Nakayama
{"title":"二膦酸盐在曲酸中引入膦酸基","authors":"Hideko Maeda, Kaori Morita, Ayaka Murokawa, Rika Matsuo, H. Nariai, H. Nakayama","doi":"10.3363/prb.35.55","DOIUrl":null,"url":null,"abstract":"Phosphonylation of kojic acid has been achieved using inorganic diphosphonate (DP) in aqueous solution. The optimum condition for the phosphonylation of kojic acid with DP is kojic acid : DP = 0.1 mol/L : 0.5 mol/L, pH 9 and 25 oC. 2-Phosphonylmethyl-kojic acid was synthesized with the yield of 45 %. The reaction mechanism of kojic acid with DP was discussed. We have successfully introduced the phosphonate group in kojic acid. Phosphonylated kojic acid is expected that the permeability of kojic acid into the skin will be increased by introducing a phosphonate group. (Received Nov 2, 2019; Accepted Nov 18, 2019)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"12 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"INTRODUCTION OF PHOSPHONATE GROUP INTO KOJIC ACID BY DIPHOSPHONATE\",\"authors\":\"Hideko Maeda, Kaori Morita, Ayaka Murokawa, Rika Matsuo, H. Nariai, H. Nakayama\",\"doi\":\"10.3363/prb.35.55\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Phosphonylation of kojic acid has been achieved using inorganic diphosphonate (DP) in aqueous solution. The optimum condition for the phosphonylation of kojic acid with DP is kojic acid : DP = 0.1 mol/L : 0.5 mol/L, pH 9 and 25 oC. 2-Phosphonylmethyl-kojic acid was synthesized with the yield of 45 %. The reaction mechanism of kojic acid with DP was discussed. We have successfully introduced the phosphonate group in kojic acid. Phosphonylated kojic acid is expected that the permeability of kojic acid into the skin will be increased by introducing a phosphonate group. (Received Nov 2, 2019; Accepted Nov 18, 2019)\",\"PeriodicalId\":20022,\"journal\":{\"name\":\"Phosphorus Research Bulletin\",\"volume\":\"12 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phosphorus Research Bulletin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3363/prb.35.55\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phosphorus Research Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3363/prb.35.55","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
INTRODUCTION OF PHOSPHONATE GROUP INTO KOJIC ACID BY DIPHOSPHONATE
Phosphonylation of kojic acid has been achieved using inorganic diphosphonate (DP) in aqueous solution. The optimum condition for the phosphonylation of kojic acid with DP is kojic acid : DP = 0.1 mol/L : 0.5 mol/L, pH 9 and 25 oC. 2-Phosphonylmethyl-kojic acid was synthesized with the yield of 45 %. The reaction mechanism of kojic acid with DP was discussed. We have successfully introduced the phosphonate group in kojic acid. Phosphonylated kojic acid is expected that the permeability of kojic acid into the skin will be increased by introducing a phosphonate group. (Received Nov 2, 2019; Accepted Nov 18, 2019)
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
