牛皮癣的代谢综合征

Anna Szponar-Bojda, D. Krasowska, A. Pietrzak, G. Chodorowska
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引用次数: 0

摘要

近年来的研究揭示了代谢综合征与牛皮癣之间的联系。两种疾病发病机制的共同因素,主要与严重炎症有关,可能是银屑病患者代谢综合征发生率增加的原因。目的:评价银屑病患者代谢综合征的危险因素的患病率,以及这些因素在银屑病严重程度中的可能作用。材料与方法:117例成年银屑病患者与对照组比较。采用PASI和mNAPSI评分评价银屑病的严重程度。进行了基本的实验室检查。测定每位患者的身体质量指数(BMI)、德炎比和血压。结果:银屑病组体重超标、BMI异常发生率明显高于银屑病组。计算出德炎比的患者体重指数和体重明显高于其他受试者。银屑病组红细胞沉降率和c反应蛋白水平明显升高,且与BMI呈正相关。与对照组相比,银屑病患者的收缩压和舒张压值明显较高,但与PASI和mNAPSI评分评估的银屑病严重程度无关。结论:我们的研究结果表明,无论代谢综合征是否完全表现出来,银屑病患者出现高血压、肥胖、肝功能障碍、炎症参数升高等代谢紊乱的风险都高于健康人群。我们建议银屑病患者应定期筛查上述疾病的存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Original paper Metabolic syndrome in psoriasis
Introduction: Recent years’ studies have revealed a link between the metabolic syndrome and psoriasis. The com mon elements of pathogenesis of both diseases, primarily associated with severe inflammation, may be responsi ble for an increased incidence of metabolic syndrome components in psoriasis patients. Aim: To evaluate the prevalence of selected risk factors for the metabolic syndrome in patients with psoriasis and possible involvement of these factors in the severity of psoriasis. Material and methods: The study included 117 adult psoriatic patients compared with a control group. The severi ty of psoriasis was evaluated using the PASI and mNAPSI score. Basic laboratory tests were performed. The body mass index (BMI), De Ritis ratio and blood pressure were determined for each patient. Results: In the psoriasis group, excess body weight and abnormal values of BMI were significantly more frequent. Body mass index and body weight were significantly higher in patients with the calculated De Ritis ratio than in other subjects. The levels of erythrocyte sedimentation rate and C-reactive protein were significantly higher in the psoriasis group and positively correlated with BMI. Compared with controls, patients with psoriasis had significantly higher values of systolic and diastolic blood pressure, with no correlation with the severity of psoriasis evaluated using the PASI and mNAPSI score. Conclusions: The results obtained in our study indicate that psoriatic patients appear to be at a higher risk of the metabolic disorders such as hypertension, obesity, liver dysfunction, increased inflammatory parameters than healthy subjects, irrespective of the full manifestation of the metabolic syndrome. We suggest that patients with psoriasis should be routinely screened for the presence of the above-mentioned disorders.
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