{"title":"模拟逆流色谱系统瞬态和稳态行为的模型研究","authors":"Bee-Gim Lim, Chi-Bun Ching","doi":"10.1016/0956-9618(95)00138-7","DOIUrl":null,"url":null,"abstract":"<div><p>A simulated counter-current chromatographic (SCC) separation process is simulated using a dispersed plug flow model with a direct approach. The solution of the governing partial differential equations is solved with a numerical technique based on the method of orthogonal collocation. Mass transfer resistances and axial dispersion are accounted for in the model. This model is used to simulate the separation of praziquantel enantiomers in the SCC system. The model accounts fully the sequential operation of the system. The transient and steady state behaviour of the separation of praziquantel enantiomers by this chromatographic system can be described adequately by this model.</p></div>","PeriodicalId":101160,"journal":{"name":"Separations Technology","volume":"6 1","pages":"Pages 29-41"},"PeriodicalIF":0.0000,"publicationDate":"1996-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0956-9618(95)00138-7","citationCount":"13","resultStr":"{\"title\":\"Modelling studies on the transient and steady state behaviour of a simulated counter-current chromatographic system\",\"authors\":\"Bee-Gim Lim, Chi-Bun Ching\",\"doi\":\"10.1016/0956-9618(95)00138-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A simulated counter-current chromatographic (SCC) separation process is simulated using a dispersed plug flow model with a direct approach. The solution of the governing partial differential equations is solved with a numerical technique based on the method of orthogonal collocation. Mass transfer resistances and axial dispersion are accounted for in the model. This model is used to simulate the separation of praziquantel enantiomers in the SCC system. The model accounts fully the sequential operation of the system. The transient and steady state behaviour of the separation of praziquantel enantiomers by this chromatographic system can be described adequately by this model.</p></div>\",\"PeriodicalId\":101160,\"journal\":{\"name\":\"Separations Technology\",\"volume\":\"6 1\",\"pages\":\"Pages 29-41\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0956-9618(95)00138-7\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Separations Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0956961895001387\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Separations Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0956961895001387","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Modelling studies on the transient and steady state behaviour of a simulated counter-current chromatographic system
A simulated counter-current chromatographic (SCC) separation process is simulated using a dispersed plug flow model with a direct approach. The solution of the governing partial differential equations is solved with a numerical technique based on the method of orthogonal collocation. Mass transfer resistances and axial dispersion are accounted for in the model. This model is used to simulate the separation of praziquantel enantiomers in the SCC system. The model accounts fully the sequential operation of the system. The transient and steady state behaviour of the separation of praziquantel enantiomers by this chromatographic system can be described adequately by this model.
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