碳酸钾对氧化物的反应对石榴产生了衍生品的作用

Ronald Zech, Hermann Engelhard, Wolf-Dietter Erdmann
{"title":"碳酸钾对氧化物的反应对石榴产生了衍生品的作用","authors":"Ronald Zech,&nbsp;Hermann Engelhard,&nbsp;Wolf-Dietter Erdmann","doi":"10.1016/0926-6593(66)90183-4","DOIUrl":null,"url":null,"abstract":"<div><p><em>Reactions of pyridinium oximes with the alkyl phosphate dimethoate and its derivatives. Effects upon cholinesterases</em></p><ul><li><span>1.</span><span><p>1. Dimethoate (Rogor), a dimethoxydithioalkyl phosphate, does not inhibit the enzymes acetylcholinesterase (EC 3.1.1.7) and cholinesterase (EC 3.1.1.8). An isomerization product (the dithiol derivative) and an oxidation product (the O analogue) may be responsible for observed inhibitory effects. These derivatives are relatively weak inhibitors of cholinesterases.</p></span></li><li><span>2.</span><span><p>2. An attempt was made to reactivate the cholinesterases inhibited by these dimethoate derivatives. All the pyridinium oximes employed produced a stronger inhibition of the enzymes, if the concentrations of alkyl phosphate and oxime were high enough.</p></span></li><li><span>3.</span><span><p>3. A reaction scheme with a possible explanation for these effects is discussed.</p></span></li></ul></div>","PeriodicalId":100160,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation","volume":"128 2","pages":"Pages 363-371"},"PeriodicalIF":0.0000,"publicationDate":"1966-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6593(66)90183-4","citationCount":"5","resultStr":"{\"title\":\"Reaktionen von pyridinium oximen mit dem alkylphosphat dimethoat und seinen derivaten wirkung auf cholinesterasen\",\"authors\":\"Ronald Zech,&nbsp;Hermann Engelhard,&nbsp;Wolf-Dietter Erdmann\",\"doi\":\"10.1016/0926-6593(66)90183-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><em>Reactions of pyridinium oximes with the alkyl phosphate dimethoate and its derivatives. Effects upon cholinesterases</em></p><ul><li><span>1.</span><span><p>1. Dimethoate (Rogor), a dimethoxydithioalkyl phosphate, does not inhibit the enzymes acetylcholinesterase (EC 3.1.1.7) and cholinesterase (EC 3.1.1.8). An isomerization product (the dithiol derivative) and an oxidation product (the O analogue) may be responsible for observed inhibitory effects. These derivatives are relatively weak inhibitors of cholinesterases.</p></span></li><li><span>2.</span><span><p>2. An attempt was made to reactivate the cholinesterases inhibited by these dimethoate derivatives. All the pyridinium oximes employed produced a stronger inhibition of the enzymes, if the concentrations of alkyl phosphate and oxime were high enough.</p></span></li><li><span>3.</span><span><p>3. A reaction scheme with a possible explanation for these effects is discussed.</p></span></li></ul></div>\",\"PeriodicalId\":100160,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation\",\"volume\":\"128 2\",\"pages\":\"Pages 363-371\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1966-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6593(66)90183-4\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0926659366901834\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926659366901834","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5

摘要

氧胺吡啶与磷酸烷基乐果及其衍生物的反应。对胆碱酯酶的影响乐果是一种二甲氧基二硫代烷基磷酸盐,对乙酰胆碱酯酶(EC 3.1.1.7)和胆碱酯酶(EC 3.1.1.8)无抑制作用。异构化产物(二硫醇衍生物)和氧化产物(O类似物)可能导致观察到的抑制作用。这些衍生物是相对较弱的胆碱酯酶抑制剂。试图重新激活被这些乐果衍生物抑制的胆碱酯酶。如果磷酸烷基和肟的浓度足够高,所使用的所有吡啶肟对酶都有较强的抑制作用。讨论了一种可能解释这些效应的反应方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reaktionen von pyridinium oximen mit dem alkylphosphat dimethoat und seinen derivaten wirkung auf cholinesterasen

Reactions of pyridinium oximes with the alkyl phosphate dimethoate and its derivatives. Effects upon cholinesterases

  • 1.

    1. Dimethoate (Rogor), a dimethoxydithioalkyl phosphate, does not inhibit the enzymes acetylcholinesterase (EC 3.1.1.7) and cholinesterase (EC 3.1.1.8). An isomerization product (the dithiol derivative) and an oxidation product (the O analogue) may be responsible for observed inhibitory effects. These derivatives are relatively weak inhibitors of cholinesterases.

  • 2.

    2. An attempt was made to reactivate the cholinesterases inhibited by these dimethoate derivatives. All the pyridinium oximes employed produced a stronger inhibition of the enzymes, if the concentrations of alkyl phosphate and oxime were high enough.

  • 3.

    3. A reaction scheme with a possible explanation for these effects is discussed.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信