Deposition of Inhaled Particles: Discussion of Present Modeling Techniques

ABSTRACT A mathematical model of particle deposition in the mammalian respiratory system should include the following elements: morphology and geometry of the lung, gas flow structure in the inspiration–expiration cycle, and pattern of particle deposition as a result of particle mass and geometry coupled with the first two elements. The particle trajectory concept and particles population balance concept are discussed as the ways for calculating the efficiency of deposition. The influence of the particle shape, growth caused by water vapor deposition, coagulation, and deformation of the airways on the deposition is emphasized.