Hernan Terroba, Alejandra González, Diana Vera Gonzalez, Roxana Mariela Godoy, A. Santos, Marisol Arrojo
{"title":"粪圆杆菌过度感染与播散性结核","authors":"Hernan Terroba, Alejandra González, Diana Vera Gonzalez, Roxana Mariela Godoy, A. Santos, Marisol Arrojo","doi":"10.18297/jri/vol5/iss1/24","DOIUrl":null,"url":null,"abstract":"Asymptomatic infection due to Strongyloides stercoralis may result in severe disease after treatment with systemic steroids. A case of S. stercoralis hyperinfection in a woman who was treated with systemic steroids for cerebral tuberculosis is reported. A 52-year-old female patient was admitted for a brain space–occupying lesion. A biopsy revealed tuberculoid-like giant cells necrotizing granulomatous reaction. Antituberculous (anti-tb) therapy and corticosteroids were started for suspected cerebral tuberculosis. Ten days after admission, the patient developed respiratory failure. A chest computed tomography showed multiple dense peripheral nodular infiltrates not seen at admission chest x-ray. Taking the patient’s epidemiological background into account, ivermectin treatment was initiated, leading to clear improvement in her clinical condition. S. stercoralis was isolated from a fecal sample. Ivermectin empirical treatment before initiation of high-dose corticosteroids in patients from endemic areas could be the best strategy for prevention of hyperinfection by this parasite.","PeriodicalId":91979,"journal":{"name":"The University of Louisville journal of respiratory infections","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Strongyloides stercoralis hyperinfection and disseminated tuberculosis\",\"authors\":\"Hernan Terroba, Alejandra González, Diana Vera Gonzalez, Roxana Mariela Godoy, A. Santos, Marisol Arrojo\",\"doi\":\"10.18297/jri/vol5/iss1/24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Asymptomatic infection due to Strongyloides stercoralis may result in severe disease after treatment with systemic steroids. A case of S. stercoralis hyperinfection in a woman who was treated with systemic steroids for cerebral tuberculosis is reported. A 52-year-old female patient was admitted for a brain space–occupying lesion. A biopsy revealed tuberculoid-like giant cells necrotizing granulomatous reaction. Antituberculous (anti-tb) therapy and corticosteroids were started for suspected cerebral tuberculosis. Ten days after admission, the patient developed respiratory failure. A chest computed tomography showed multiple dense peripheral nodular infiltrates not seen at admission chest x-ray. Taking the patient’s epidemiological background into account, ivermectin treatment was initiated, leading to clear improvement in her clinical condition. S. stercoralis was isolated from a fecal sample. Ivermectin empirical treatment before initiation of high-dose corticosteroids in patients from endemic areas could be the best strategy for prevention of hyperinfection by this parasite.\",\"PeriodicalId\":91979,\"journal\":{\"name\":\"The University of Louisville journal of respiratory infections\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The University of Louisville journal of respiratory infections\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18297/jri/vol5/iss1/24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The University of Louisville journal of respiratory infections","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18297/jri/vol5/iss1/24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Strongyloides stercoralis hyperinfection and disseminated tuberculosis
Asymptomatic infection due to Strongyloides stercoralis may result in severe disease after treatment with systemic steroids. A case of S. stercoralis hyperinfection in a woman who was treated with systemic steroids for cerebral tuberculosis is reported. A 52-year-old female patient was admitted for a brain space–occupying lesion. A biopsy revealed tuberculoid-like giant cells necrotizing granulomatous reaction. Antituberculous (anti-tb) therapy and corticosteroids were started for suspected cerebral tuberculosis. Ten days after admission, the patient developed respiratory failure. A chest computed tomography showed multiple dense peripheral nodular infiltrates not seen at admission chest x-ray. Taking the patient’s epidemiological background into account, ivermectin treatment was initiated, leading to clear improvement in her clinical condition. S. stercoralis was isolated from a fecal sample. Ivermectin empirical treatment before initiation of high-dose corticosteroids in patients from endemic areas could be the best strategy for prevention of hyperinfection by this parasite.