阿尔茨海默病在未来十年的管理

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Immanuel Sani
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引用次数: 0

摘要

自从临床神经科学成立以来,科学上的突破增强了我们对某些病理如何损害神经系统功能的认识。由于人口老龄化,阿尔茨海默病(Alzheimer’s disease, AD)是现代临床神经科学中一个永恒的挑战,这使得个体对阿尔茨海默病的易感性越来越高。在全球范围内,阿尔茨海默氏症是最常见的痴呆症形式,从1990年到2016年,全球痴呆症患者人数增加了一倍多,这就需要迅速开发有效的干预措施,阻止或延缓疾病进展。这篇叙述性综述建议进一步研究单克隆抗体治疗早期AD患者的有效性,并利用几种实验室工具来了解AD的复杂病因。在未来的十年里,希望本文的建议能够成为现实,促进临床神经科学的进一步发展,开发出延缓甚至逆转目前预后较差的AD临床表现的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Management of Alzheimer’s disease in the next ten years
Since the inception of clinical neuroscience, scientific breakthroughs have enhanced our knowledge of how certain pathologies impair the function of the nervous system. Alzheimer’s disease (AD) is a perpetual challenge in modern clinical neuroscience due to the ageing population, which makes individuals increasingly susceptible to AD. On a global scale, AD is the most common form of dementia and the number of people living with dementia worldwide has more than doubled from 1990 to 2016, which warrants prompt development of effective interventions that may halt or delay disease progression. This narrative review recommends further investigation into the effectiveness of monoclonal antibody treatment in patients with early AD and the utilisation of several laboratory tools to understand the complex aetiology of AD. In the next ten years, it is hoped that the recommendations in this article may come to fruition and facilitate further advancements in clinical neuroscience to develop therapies that delay the onset and even reverse the clinical manifestation of AD that currently has a poor prognosis.
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来源期刊
University of Toronto Medical Journal
University of Toronto Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.30
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