Synthesis, Characterisation and In Vitro Biological Evaluation of Novel 3-Chloro-1-(5-ethyl-[1,3,4] thiadiazole-2-yl)-4-phenyl-azetidin-2-one Derivatives

The 1,3,4-thiadiazole molecules are interesting significance in the field of health pharmaceutics and agriculture. Derivatives of 2-amino-5-ethyl-1,3,4-thiadiazole obtained by cyclization from chloroacetyl chloride in the presence of triethyl amine. Schiff base of 2-amino-5ethyl-1,3,4-thiadiazole on reaction with aromatic aldehydes afforded compound (1). This compound on further reaction with chloroacetyl chloride in the presence of Et3N yielded 3-chloro-1-(5-ethyl[1,3,4]thiadiazole-2-yl)-4methyl-azetidin-2-ones (2). Antibacterial and antifungal activities were performed on Bacillus subtilis, Escherichia coli and S tyhpi bacteria and Aspergillus niger, Aspergillus flavus and Fusarium oxisporium fungi respectively. Structures of all the synthesized compounds were confirmed using IR, H NMR and C NMR and MS spectroscopy.