Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide

: Various factors such as solubility, volatility, spray drift, runoff, and photolysis prevent the pesticides to reach their desired location and realize their full potential. In this study, additive manufacturing is used to create a drug-loaded filament that can be used in Fused deposition modeling printing. The optimal printing parameters are printing temperature (170°C), hotbed temperature (25°C), printing speed 15 mm/s, filament diameter 1.55 mm, layer height 0.3 mm, nozzle diameter 0.4 mm and zero retraction speed and retraction distance. The PCL-based framework provides a scaffold for drug encapsulation and low melting temperature. The latter is the key to maintaining the integrity and chemical properties of the loaded drug. FTIR confirms the physical-mix nature of composite. XRD suggests that PCL and model drug became amorphous after printing. The PCL controlled-release can be realized through in vitro dissolution tests. Among the four kinetic models: the zero-order, first-order, Higuchi model, and Korsmeyer–Peppas model, the kinetic model for dissolution and drug release conforms to the Korsmeyer– Peppas model. This study provides a viable design of controlled-release pesticides by adjusting the release regulator content and type to meet the precision pest-control needs. This 3DP tablet has higher drug loading, controllable drug loading, stable drug release ability, UV shielding performance, and an easy manufacturing process. There is no need for expensive and special equipment to produce the desired functionality, which greatly reduces production costs and simplifies the production process.