{"title":"通过抑制胆固醇酯转移蛋白提高HDL-C","authors":"Adie Viljoen MMed, FRCPath, MBA, Anthony Wierzbicki DM, DPhil, FRCPath, FAHA","doi":"10.1002/fps.77","DOIUrl":null,"url":null,"abstract":"<p><b>Plasma concentrations of high-density lipoprotein cholesterol (HDL-C) and its major protein component apolipoprotein (apo) A-I are strongly inversely correlated with cardiovascular risk, leading to the notion that therapy to increase HDL-C and apoA-I concentrations would be antiatherosclerotic and protective against cardiovascular disease (CVD) events.1,2 In this article, the authors discuss how inhibition of cholesteryl ester transfer protein (CETP) could potentially lead to an increase in HDL-C with a subsequent reduction in CVD events, a hypothesis being tested by the development of the drugs anacetrapib and dalcetrapib.</b></p>","PeriodicalId":100566,"journal":{"name":"Future Prescriber","volume":"12 2","pages":"12-15"},"PeriodicalIF":0.0000,"publicationDate":"2011-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/fps.77","citationCount":"0","resultStr":"{\"title\":\"Raising HDL-C through cholesteryl ester transfer protein inhibition\",\"authors\":\"Adie Viljoen MMed, FRCPath, MBA, Anthony Wierzbicki DM, DPhil, FRCPath, FAHA\",\"doi\":\"10.1002/fps.77\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Plasma concentrations of high-density lipoprotein cholesterol (HDL-C) and its major protein component apolipoprotein (apo) A-I are strongly inversely correlated with cardiovascular risk, leading to the notion that therapy to increase HDL-C and apoA-I concentrations would be antiatherosclerotic and protective against cardiovascular disease (CVD) events.1,2 In this article, the authors discuss how inhibition of cholesteryl ester transfer protein (CETP) could potentially lead to an increase in HDL-C with a subsequent reduction in CVD events, a hypothesis being tested by the development of the drugs anacetrapib and dalcetrapib.</b></p>\",\"PeriodicalId\":100566,\"journal\":{\"name\":\"Future Prescriber\",\"volume\":\"12 2\",\"pages\":\"12-15\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/fps.77\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future Prescriber\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/fps.77\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Prescriber","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/fps.77","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Raising HDL-C through cholesteryl ester transfer protein inhibition
Plasma concentrations of high-density lipoprotein cholesterol (HDL-C) and its major protein component apolipoprotein (apo) A-I are strongly inversely correlated with cardiovascular risk, leading to the notion that therapy to increase HDL-C and apoA-I concentrations would be antiatherosclerotic and protective against cardiovascular disease (CVD) events.1,2 In this article, the authors discuss how inhibition of cholesteryl ester transfer protein (CETP) could potentially lead to an increase in HDL-C with a subsequent reduction in CVD events, a hypothesis being tested by the development of the drugs anacetrapib and dalcetrapib.
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