清醒大鼠压力利尿的状态依赖性表达。

J. Steele, L. Koch, P. H. Brand
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引用次数: 2

摘要

1967年,Guyton和Coleman将压力利尿建模为钠摄入量改变时调节动脉压力的潜在、必要和长期机制。影响肾功能的其他机制与利尿压力相互作用以达到钠平衡并决定血压。钠摄入量的增加抑制了钠保存机制,激活了利钠机制;钠摄入量的减少会产生相反的效果。如果盖顿-科尔曼模型是正确的,那么在高盐饮食的动物身上比在低盐饮食的动物身上更容易检测到压力利尿。我们测量了低盐(0。4% NaCl)和高盐(8.0% NaCl)饲料。对于喂食高盐饮食的10只大鼠,在32个试验中有19个(59%)的动脉压和尿流量呈正相关。在10只喂食低盐饮食的大鼠中,33个试验中有10个(30%)观察到正相关。卡方分析显示,饮食中Na+含量的差异与血压和尿流量呈正相关的概率显著相关。这些结果支持了压力利尿在时间上的表达依赖于钠平衡状态的假设。
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State-dependent expression of pressure diuresis in conscious rats.
In 1967, Guyton and Coleman modeled pressure diuresis as the underlying, essential, long-term mechanism that regulates arterial pressure when sodium intake changes. Other mechanisms that influence renal function interact with pressure diuresis to achieve sodium balance and determine the blood pressure. Increases in sodium intake suppress sodium conserving mechanisms and activate natriuretic mechanisms; decreases in sodium intake have the opposite effect. If the Guyton-Coleman model is correct, then pressure diuresis should be more readily detected in animals on a high-salt diet than in animals on a low-salt diet. We measured spontaneous changes in arterial pressure and urine flow in conscious rats fed low-salt (0. 4% NaCl) and high-salt (8.0% NaCl) chow. For 10 rats fed a high-salt diet, arterial pressure and urine flow were positively correlated in 19 of 32 (59%) trials. In 10 rats fed a low-salt diet, a positive correlation was observed in 10 of 33 (30%) trials. Chi-square analysis revealed that differences in Na+ content of the diet were significantly associated with the probability of a positive relationship between blood pressure and urine flow. These results support the hypothesis that the expression of pressure diuresis across time is dependent on the state of sodium balance.
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