尼日利亚东北部迈杜古里巨细胞病毒IgG抗体的母婴转移

T. M. Adisa, D. Bukbuk, T. Harry
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引用次数: 3

摘要

采用酶联免疫吸附试验(ELISA)技术对迈杜古里国家专科医院94名产妇及其新生儿进行巨细胞病毒(CMV) IgG抗体转移的血清学研究。使用的ELISA技术是BIOTEC商用试剂盒,检测CMV特异性IgG。在94名母亲中,93名(98.9%)有CMV IgG抗体,而相应的新生儿血清阳性率为86.2%(93名中有81名)。按新生儿性别划分,男、女患病率分别为86.3%(44 / 93)和69.8%(37 / 93)。新生儿对巨细胞病毒感染的免疫率为87.1%,易感率为12.9%。母体CMV IgG抗体与母体年龄(r = 0.57)、胎龄(r = 0.03)、妊娠次数(r = 0.03)呈正相关。在这项研究中,大多数(87.1%)母亲对巨细胞病毒感染免疫,并且能够给新生儿提供足够的保护(巨细胞病毒IgG),使一小部分(12.9%)新生儿对巨细胞病毒易感。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Maternofoetal transfer of Cytomegalovirus IgG antibodies in Maiduguri, North Eastern Nigeria
A serological study to determine the transfer of Cytomegalovirus (CMV) IgG antibody between 94 mothers and their newborns attending the State Specialist Hospital, Maiduguri was carried out using Enzyme Linked Immunosorbent Assay (ELISA) technique. The ELISA technique used was a commercial kit BIOTEC which detects IgG specific to CMV.Of the 94 mothers tested, 93 (98.9%) have CMV IgG antibody while their corresponding newborns had 86.2% (81 out of 93) seroprevalence rate. The percentage prevalence according to sex of the newborns was 86.3% (44 out of 93) and 69.8% (37 out of 93) males and females respectively. About 87.1% of the newborns were immune to CMV infection compared with 12.9% susceptible.There was a positive correlation between maternal CMV IgG antibody with maternal age (r = 0.57), gestational age (r = 0.03) and the number of pregnancies (r = 0.03).Most (87.1%) mothers in the study are immune to CMV infection and were able to pass adequate protection (CMV IgG) to their newborns leaving a small (12.9%) proportion of susceptible newborns to CMV.
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