药物明胶薄膜降解动力学的无线筛选

2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Pub Date : 2015-06-21 DOI:10.1109/TRANSDUCERS.2015.7181319

H. Jiang, M. Ochoa, J. H. Park, A. Otte, R. Pinal, B. Ziaie

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引用次数: 5

摘要

我们开发了一种用于明胶薄膜物理降解快速筛选的无线传感方案。该技术提出了一种描述初始溶胀(电容变化)和随后溶解(电感变化)相的新方法。这是通过将超顺磁性纳米颗粒结合到固定在平面电感器顶部的明胶薄膜中来实现的。通过无线测量降解动力学来识别溶胀和溶解相，前60分钟的灵敏度为2313.4 kHz /吸光度单位，60分钟至540分钟的灵敏度为2214.2 kHz /吸光度单位。

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Wireless screenning of degradation kinetics in pharmaceutical gelatin films

We have developed a wireless sensing scheme for rapid screening of gelatin film physical degradation. The technique presents a new method for delineating the initial swelling (capacitive change) and subsequent dissolution (inductive change) phases. This is accomplished by incorporating super-paramagnetic nanoparticles into a gelatin film that is immobilized on top of a planar inductor. The degradation kinetics are measured wirelessly to identify the swelling and dissolution phases with sensitivities of 2313.4 kHz per absorbance unit during the first 60 minutes and 2214.2 kHz per absorbance unit from 60 minutes to 540 minutes.

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2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)

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