Eosinophilic granulomatosis with Anti-MPO-C-ANCA-associated polyangitis: a case report illustrating the diagnosis difficulty

Eosinophilic granulomatosis with polyangitis (EGPA), formerly known as Churg-Strauss syndrome, with antineutrophil cytoplasmic autoantibodies (ANCA) is a rare vasculitis. The CANCA is mainly antibodies to proteinase-3 and the P-ANCA is antibodies to myeloperoxidase (MPO). The EGPA with C-ANCA with antibodies anti-MPO has never been described in Subsaharan Africa. Medical investigations allowed excluding infectious diseases, malignancies and other rheumatic affections. Thus, clinical and paraclinical data suggested an atypic EGPA with MPO-C-ANCA. In our knoweledge, we reported here the first case of EGPA wtih MPO C-ANCA from Madagascar. The EGPA was succesfully controled with steroid treatment.