{"title":"心脏修复与再生","authors":"D. Lunn, Vanessa Wazny, S. Cutie, Guo N. Huang","doi":"10.4172/2168-9296.1000193","DOIUrl":null,"url":null,"abstract":"The regenerative capacity of the heart varies drastically across the animal kingdom. Certain species, such as zebrafish and newts, display a remarkable innate ability for heart regeneration. In contrast, heart regeneration in adult mammals is limited. Heart regenerative potential also varies during organismal development. For example, while neonatal mice can regenerate their hearts, this is lost during the first week after birth. Understanding cardiac regenerative pathways will play a critical role in discovering therapeutic approaches to stimulate human cardiac regeneration. In this review, we explore the known strategies to stimulate intrinsic heart regeneration and highlight current cell replacement therapies.","PeriodicalId":9775,"journal":{"name":"Cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Cardiac Repair and Regeneration\",\"authors\":\"D. Lunn, Vanessa Wazny, S. Cutie, Guo N. Huang\",\"doi\":\"10.4172/2168-9296.1000193\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The regenerative capacity of the heart varies drastically across the animal kingdom. Certain species, such as zebrafish and newts, display a remarkable innate ability for heart regeneration. In contrast, heart regeneration in adult mammals is limited. Heart regenerative potential also varies during organismal development. For example, while neonatal mice can regenerate their hearts, this is lost during the first week after birth. Understanding cardiac regenerative pathways will play a critical role in discovering therapeutic approaches to stimulate human cardiac regeneration. In this review, we explore the known strategies to stimulate intrinsic heart regeneration and highlight current cell replacement therapies.\",\"PeriodicalId\":9775,\"journal\":{\"name\":\"Cell & developmental biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell & developmental biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2168-9296.1000193\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell & developmental biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2168-9296.1000193","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The regenerative capacity of the heart varies drastically across the animal kingdom. Certain species, such as zebrafish and newts, display a remarkable innate ability for heart regeneration. In contrast, heart regeneration in adult mammals is limited. Heart regenerative potential also varies during organismal development. For example, while neonatal mice can regenerate their hearts, this is lost during the first week after birth. Understanding cardiac regenerative pathways will play a critical role in discovering therapeutic approaches to stimulate human cardiac regeneration. In this review, we explore the known strategies to stimulate intrinsic heart regeneration and highlight current cell replacement therapies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
