β-酮腈、4-氟苯甲醛和仲环胺的三组分缩合

Reactions Pub Date : 2022-12-12 DOI:10.3390/reactions3040042

D. Osipov, K. S. Korzhenko, V. Osyanin

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引用次数: 0

摘要

研究了一种由β-酮腈、4-氟苯甲醛和仲环胺组成的新型三组分缩合物。提出了一种可能的反应机理，包括Knoevenagel缩合和芳香亲核取代。结果表明，在含6-氨基-1,3-二甲基尿嘧啶基团的3-氧丙腈反应中，Knoevenagel加合物中不伴有氟的取代，而在Michael加成后发生氧化反应。

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Three-Component Condensation of β-Ketonitriles, 4-Fluorobenzaldehyde, and Secondary Cyclic Amines

A new three-component condensation of β-ketonitriles, 4-fluorobenzaldehyde, and secondary cyclic amines was developed. A possible reaction mechanism has been proposed including Knoevenagel condensation followed by aromatic nucleophilic substitution. It was found that in the case of 3-oxopropanenitrile bearing the 6-amino-1,3-dimethyluracil moiety, the reaction is not accompanied by fluorine substitution in the Knoevenagel adduct, and the Michael addition of a secondary amine occurs followed by oxidation.

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Reactions

CiteScore

2.70

自引率

0.00%

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