肾移植受者下肢外周动脉疾病及其与不良结局的关系:一项回顾性队列研究

Q4 Medicine
L. C. Álvarez-Perdomo, J. U. Cataño-Bedoya, Maribel Plaza-Tenorio, Ana María Botero-Mora, Isabel del Pilar Cardozo-Moreno, L. M. Barrera-Lozano, J. A. Ramírez-Arbeláez, Carlos-Martín Ardila
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引用次数: 0

摘要

本研究的目的是描述一系列肾移植患者的下肢外周动脉疾病(LEPAD),并评估其对不良结局的影响。一项回顾性队列研究包括接受LEPAD筛查的肾移植患者。评估的结果分为围手术期和移植后,包括心血管事件、截肢、死亡率和移植物丢失。共有141例肾移植患者接受LEPAD筛查,平均随访3年。LEPAD发生率为14.2%(20/141)。除吸烟外,两组间心血管危险因素无显著差异(45%比24%,p < 0.05)。在LEPAD组中,最受损的解剖节段是髌下肌,未发现髂受累。Cox比例风险模型显示,年龄、性别和体重对LEPAD患者有显著影响。两组之间在移植物损失和死亡方面没有差异。肾移植合并LEPAD患者最大的狭窄区域是肾下段。与吸烟一起,它们可以解释肾移植患者主要截肢的存在;然而,它们对移植物功能或死亡没有影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lower Extremity Peripheral Arterial Disease and Its Relationship with Adverse Outcomes in Kidney Transplant Recipients: A Retrospective Cohort Study
The purpose of the study was to characterize lower extremity peripheral arterial disease (LEPAD) in a series of kidney transplant patients and to assess the impact on adverse outcomes. A retrospective cohort study was conducted including kidney transplant recipient patients who underwent screening for LEPAD. The outcomes evaluated were classified as perioperative and post-transplant, including cardiovascular events, amputation, mortality, and loss of the graft. A total of 141 renal transplant patients screened for LEPAD were identified, with an average follow-up of 3 years. LEPAD occurred in 14.2% (20/141). No differences in cardiovascular risk factors were found between the groups, except for smoking (45% vs. 24%, p < 0.05). In the group with LEPAD, the most compromised anatomical segment was the infrapopliteus, with no iliac involvement found. The Cox proportional hazards model indicated that the variables age, gender, and weight were significant in patients with LEPAD. There were no differences between the groups in terms of graft loss and death. The infrapopliteal segment is the area of greatest stenosis in kidney transplant patients with LEPAD. Together with smoking, they can explain the presence of major amputations in kidney transplant patients; however, they had no impact on graft functionality or death.
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来源期刊
Cell and Organ Transplantology
Cell and Organ Transplantology Medicine-Transplantation
CiteScore
0.40
自引率
0.00%
发文量
8
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